Crystallographic legacy of Ned Seeman


      We trace the career path of Nadrian Seeman, the inventor of DNA nanotechnology. The influence of his early training in crystallography and how this led to his success in creating self-assembled crystals are highlighted.
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        • Jeffrey G.A.
        An Introduction to Hydrogen Bonding.
        Oxford University Press, New York1997
      1. 2014.

        • Sussman J.L.
        • Seeman N.C.
        • Berman H.M.
        • et al.
        Crystal structure of a naturally occurring dinucleoside phosphate: uridylyl 3′, 5′-adenosine phosphate model for RNA chain folding.
        J. Mol. Biol. 1972; 66: 403-421
        • Seeman N.C.
        • Rosenberg J.M.
        • Rich A.
        • et al.
        RNA double-helical fragments at atomic resolution: I. The crystal and molecular structure of sodium adenylyl-3′, 5′-uridine hexahydrate.
        J. Mol. Biol. 1976; 104: 109-144
        • Rosenberg J.M.
        • Seeman N.C.
        • Rich A.
        • et al.
        RNA double-helical fragments at atomic resolution: II. The crystal structure of sodium guanylyl-3′, 5′-cytidine nonahydrate.
        J. Mol. Biol. 1976; 104: 145-167
        • Seeman N.C.
        • Rosenberg J.M.
        • Rich A.
        Sequence-specific recognition of double helical nucleic acids by proteins.
        Proc. Natl. Acad. Sci. USA. 1976; 73: 804-808
        • Egli M.
        • Zhang S.
        First prediction of sequence-specific recognition of double-helix nucleic acids by proteins.
        Nat. Rev. Mol. Cell Biol. 2022; 23: 166
        • Seeman N.C.
        De novo design of sequences for nucleic acid structural engineering.
        J. Biomol. Struct. Dyn. 1990; 8: 573-581
        • Qiu H.
        • Dewan J.C.
        • Seeman N.C.
        A DNA decamer with a sticky end: the crystal structure of d-CGACGATCGT.
        J. Mol. Biol. 1997; 267: 881-898
        • Ball P.
        Ned Seeman (1945–2021).
        Nature. 2021; 600: 605
        • Seeman N.C.
        The crystallographic roots of DNA nanotechnology.
        ACA Reflexions. 2014; 2: 19-23
        • Zheng J.
        • Birktoft J.J.
        • Seeman N.C.
        • et al.
        From molecular to macroscopic via the rational design of a self-assembled 3D DNA crystal.
        Nature. 2009; 461: 74-77