Advertisement
Biophysical Reports
All content is freely available to readers and supported through open access

New articles

Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

September 15, 2022

Article

Deciphering the conformational dynamics of gephyrin-mediated collybistin activation

  • Nasir Imam,
  • Susobhan Choudhury,
  • Katherina Hemmen,
  • Katrin G. Heinze,
  • Hermann Schindelin
First published:September 15, 2022
Efficient neuronal signaling depends on the proper assembly of the postsynaptic neurotransmitter machinery. The majority of inhibitory synapses feature gamma-aminobutyric acid type-A (GABAA) receptors. The function of these GABAergic synapses is controlled by the scaffolding protein gephyrin and collybistin, a Dbl-family guanine nucleotide exchange factor and neuronal adaptor protein. Specifically, collybistin interacts with small GTPases, cell adhesion proteins and phosphoinositides to recruit gephyrin and GABAA receptors to postsynaptic membrane specializations.
Advertisement
Advertisement