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Cell Reports Medicine
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Aug 25, 2020

Volume 1Issue 5
Open Access
On the cover: Probiotic strains of Bifidobacterium and Lactobacillus shape the gut microbiota of preterm infants. See Alcon-Giner and Dalby et al., pp. 100077-1–100077-16. Photo credit: Image_jungle/iStock/Getty Images Plus via Getty Images....
On the cover: Probiotic strains of Bifidobacterium and Lactobacillus shape the gut microbiota of preterm infants. See Alcon-Giner and Dalby et al., pp. 100077-1–100077-16. Photo credit: Image_jungle/iStock/Getty Images Plus via Getty Images.

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Articles

  • Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19

    • Lucie Rodriguez,
    • Pirkka T. Pekkarinen,
    • Tadepally Lakshmikanth,
    • Ziyang Tan,
    • Camila Rosat Consiglio,
    • Christian Pou,
    • Yang Chen,
    • Constantin Habimana Mugabo,
    • Ngoc Anh Nguyen,
    • Kirsten Nowlan,
    • Tomas Strandin,
    • Lev Levanov,
    • Jaromir Mikes,
    • Jun Wang,
    • Anu Kantele,
    • Jussi Hepojoki,
    • Olli Vapalahti,
    • Santtu Heinonen,
    • Eliisa Kekäläinen,
    • Petter Brodin
    Immune dysregulation plays a pivotal role during severe COVID-19. Rodriguez et al. present a systems-level, longitudinal study of 37 COVID-19 patients monitored from acute to recovery phases of disease. This study reveals cell-protein dependencies and co-regulated features, as well as a shared immunological trajectory during recovery.
  • Point of Care Nucleic Acid Testing for SARS-CoV-2 in Hospitalized Patients: A Clinical Validation Trial and Implementation Study

    • Dami A. Collier,
    • Sonny M. Assennato,
    • Ben Warne,
    • Nyarie Sithole,
    • Katherine Sharrocks,
    • Allyson Ritchie,
    • Pooja Ravji,
    • Matthew Routledge,
    • Dominic Sparkes,
    • Jordan Skittrall,
    • Anna Smielewska,
    • Isobel Ramsey,
    • Neha Goel,
    • Martin Curran,
    • David Enoch,
    • Rhys Tassell,
    • Michelle Lineham,
    • Devan Vaghela,
    • Clare Leong,
    • Hoi Ping Mok,
    • John Bradley,
    • Kenneth G.C. Smith,
    • Vivienne Mendoza,
    • Nikos Demiris,
    • Martin Besser,
    • Gordon Dougan,
    • Paul J. Lehner,
    • Mark J. Siedner,
    • Hongyi Zhang,
    • Claire S. Waddington,
    • Helen Lee,
    • Ravindra K. Gupta
    • The CITIID-NIHR COVID BioResource Collaboration
    Collier et al. report testing and implementation of an accurate SARS-CoV-2 point of care nucleic acid amplification test that leads to faster time to definitive bed placement from the ER, release of isolation rooms, avoidance of bed closures, and expedited discharges to care homes and access to hospital investigations and procedures.
  • Safety and COVID-19 Symptoms in Individuals Recently Vaccinated with BCG: a Retrospective Cohort Study

    • Simone J.C.F.M. Moorlag,
    • Rosanne C. van Deuren,
    • Cornelis H. van Werkhoven,
    • Martin Jaeger,
    • Priya Debisarun,
    • Esther Taks,
    • Vera P. Mourits,
    • Valerie A.C.M. Koeken,
    • L. Charlotte J. de Bree,
    • Thijs ten Doesschate,
    • Maartje C. Cleophas,
    • Sanne Smeekens,
    • Marije Oosting,
    • Frank L. van de Veerdonk,
    • Leo A.B. Joosten,
    • Jaap ten Oever,
    • Jos W.M. van der Meer,
    • Nigel Curtis,
    • Peter Aaby,
    • Christine Stabell-Benn,
    • Evangelos J. Giamarellos-Bourboulis,
    • Marc Bonten,
    • Reinout van Crevel,
    • Mihai G. Netea
    Moorlag et al. show in a retrospective cohort study that recent BCG vaccination is safe and did not increase disease symptoms during the COVID-19 outbreak. Prospective randomized clinical trials are warranted to assess BCG vaccination effectiveness against SARS-CoV-2 infection.
  • Microbiota Supplementation with Bifidobacterium and Lactobacillus Modifies the Preterm Infant Gut Microbiota and Metabolome: An Observational Study

    • Cristina Alcon-Giner,
    • Matthew J. Dalby,
    • Shabhonam Caim,
    • Jennifer Ketskemety,
    • Alex Shaw,
    • Kathleen Sim,
    • Melissa A.E. Lawson,
    • Raymond Kiu,
    • Charlotte Leclaire,
    • Lisa Chalklen,
    • Magdalena Kujawska,
    • Suparna Mitra,
    • Fahmina Fardus-Reid,
    • Gustav Belteki,
    • Katherine McColl,
    • Jonathan R. Swann,
    • J. Simon Kroll,
    • Paul Clarke,
    • Lindsay J. Hall
    Alcon-Giner et al. show that probiotic supplementation in preterm infants leads to a Bifidobacterium-dominated gut microbiota, elevated acetate and lactate levels, and lower fecal pH, with concurrent reduction in pathobionts. Bifidobacterium isolation confirms strain presence; genomic and in vitro studies indicate strain encoded enzymatic clusters allowing growth on HMOs.
  • Malignant Transformation Involving CXXC4 Mutations Identified in a Leukemic Progression Model of Severe Congenital Neutropenia

    • Patricia A. Olofsen,
    • Szabolcs Fatrai,
    • Paulina M.H. van Strien,
    • Julia C. Obenauer,
    • Hans W.J. de Looper,
    • Remco M. Hoogenboezem,
    • Claudia A.J. Erpelinck-Verschueren,
    • Michael P.W.M. Vermeulen,
    • Onno Roovers,
    • Torsten Haferlach,
    • Joop H. Jansen,
    • Mehrnaz Ghazvini,
    • Eric M.J. Bindels,
    • Rebekka K. Schneider,
    • Emma M. de Pater,
    • Ivo P. Touw
    Olofsen et al. show that acquisition of a mutation in Cxxc4 results in increased CXXC4 protein levels, reduced TET2 protein, increased inflammatory signaling, and leukemic progression of a CSF3R/RUNX1 mutant mouse model of severe congenital neutropenia (SCN).
  • Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk

    • Mark R. Davies,
    • Michael Martinec,
    • Robert Walls,
    • Roman Schwarz,
    • Gary R. Mirams,
    • Ken Wang,
    • Guido Steiner,
    • Andy Surinach,
    • Carlos Flores,
    • Thierry Lavé,
    • Thomas Singer,
    • Liudmila Polonchuk
    Davies et al. analyze patient health records and FDA Adverse Event Reporting System reports to demonstrate how patient subtypes affect the incidence of drug-related arrhythmia. Using such real-world data to understand background arrhythmia can further validate cardiac risk models for regulatory use and help stratify patients when evaluating drug risk.

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