Cell Reports Medicine
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New articles

Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

September 25, 2022


Antigen- and scaffold-specific antibody responses to protein nanoparticle immunogens

  • John C. Kraft,
  • Minh N. Pham,
  • Laila Shehata,
  • Mitch Brinkkemper,
  • Seyhan Boyoglu-Barnum,
  • Kaitlin R. Sprouse,
  • Alexandra C. Walls,
  • Suna Cheng,
  • Mike Murphy,
  • Deleah Pettie,
  • Maggie Ahlrichs,
  • Claire Sydeman,
  • Max Johnson,
  • Alyssa Blackstone,
  • Daniel Ellis,
  • Rashmi Ravichandran,
  • Brooke Fiala,
  • Samuel Wrenn,
  • Marcos Miranda,
  • Kwinten Sliepen,
  • Philip J.M. Brouwer,
  • Aleksandar Antanasijevic,
  • David Veesler,
  • Andrew B. Ward,
  • Masaru Kanekiyo,
  • Marion Pepper,
  • Rogier W. Sanders,
  • Neil P. King
First published:September 25, 2022
Kraft et al. define relationships between anti-scaffold and antigen-specific antibody responses elicited by protein nanoparticle immunogens. Overall, anti-scaffold antibody responses are unlikely to suppress antigen-specific antibody responses for protein nanoparticle immunogens in which the antigen is immunodominant over the scaffold.

Longitudinal characterization of circulating neutrophils uncovers distinct phenotypes associated with severity in hospitalized COVID-19 patients

  • Thomas J. LaSalle,
  • Anna L.K. Gonye,
  • Samuel S. Freeman,
  • Paulina Kaplonek,
  • Irena Gushterova,
  • Kyle R. Kays,
  • Kasidet Manakongtreecheep,
  • Jessica Tantivit,
  • Maricarmen Rojas-Lopez,
  • Brian C. Russo,
  • Nihaarika Sharma,
  • Molly F. Thomas,
  • Kendall M. Lavin-Parsons,
  • Brendan M. Lilly,
  • Brenna N. Mckaig,
  • Nicole C. Charland,
  • Hargun K. Khanna,
  • Carl L. Lodenstein,
  • Justin D. Margolin,
  • Emily M. Blaum,
  • Paola B. Lirofonis,
  • Or-Yam Revach,
  • Arnav Mehta,
  • Abraham Sonny,
  • Roby P. Bhattacharyya,
  • Blair Alden Parry,
  • Marcia B. Goldberg,
  • Galit Alter,
  • Michael R. Filbin,
  • Alexandra Chloe Villani,
  • Nir Hacohen,
  • Moshe Sade-Feldman
First published:September 25, 2022
LaSalle et al. utilize bulk transcriptomics of neutrophils, plasma proteomics, and high-throughput antibody profiling of a large cohort of hospitalized COVID-19 patients to explore the relationship between neutrophil states and disease severity. They identify granulocytic myeloid-derived suppressor cell-like signatures and plasma IgA1-to-IgG1 ratios as predictive of disease severity and mortality.

September 18, 2022


Enhanced antibody responses in fully vaccinated individuals against pan-SARS-CoV-2 variants following Omicron breakthrough infection

  • Hye Won Jeong,
  • Se-Mi Kim,
  • Min Kyung Jung,
  • Ji Yun Noh,
  • Ji-Seung Yoo,
  • Eun-Ha Kim,
  • Young-Il Kim,
  • Kwangmin Yu,
  • Seung-Gyu Jang,
  • JuRyeon Gil,
  • Mark Anthony Casel,
  • Rollon Rare,
  • Jeong Ho Choi,
  • Hee-Sung Kim,
  • Jun Hyoung Kim,
  • Jihye Um,
  • Chaeyoon Kim,
  • Yeonjae Kim,
  • Bum Sik Chin,
  • Sungmin Jung,
  • Jun Yong Choi,
  • Kyoung-Ho Song,
  • Yong-Dae Kim,
  • Jun-Sun Park,
  • Joon Young Song,
  • Eui-Cheol Shin,
  • Young Ki Choi
First published:September 18, 2022
Jeong et al. investigate the efficacies of the NAb elicited by SARS-CoV-2 infection or mRNA vaccination. Through the longitudinal analysis, the authors demonstrate that although cross-reactivity of the NAb induced by SARS-CoV-2 infection or two-dose vaccination is variant-specific, Omicron breakthrough infection following booster vaccination can elicit NAb against pan-SARS-CoV-2.

September 12, 2022


Correlation of gut microbiota and metabolic functions with the antibody response to the BBIBP-CorV vaccine

  • Bo Tang,
  • Li Tang,
  • Wei He,
  • Xingyu Jiang,
  • Changjiang Hu,
  • Yicheng Li,
  • Yang Zhang,
  • Kun Pang,
  • Yuanyuan Lei,
  • Shengpeng Li,
  • Shuang Liu,
  • Sumin Wang,
  • Min Yang,
  • Zhongjun Li,
  • Fangqing Zhao,
  • Shiming Yang
First published:September 12, 2022
Tang et al. report that gut microbiome and functional profiles are altered following BBIBP-CorV vaccination and microbiome-related SCFAs production positively correlated to the immune response of this inactivated COVID-19 vaccine. The findings give insights into microbiota regulation in improving the performance of COVID-19 vaccines.

September 6, 2022


Disentangling the cognitive, physical, and mental health sequelae of COVID-19

  • Conor J. Wild,
  • Loretta Norton,
  • David K. Menon,
  • David A. Ripsman,
  • Richard H. Swartz,
  • Adrian M. Owen
First published:September 06, 2022
In 478 survivors of COVID-19 tested approximately 30 days after infection, Wild et al. show that cognition is affected in specific domains. Cognitive performance is positively correlated with physical but not mental health, suggesting that the subjective experience of “long COVID” consists of physical and cognitive, especially executive, symptoms.

July 25, 2022


Should Alexa diagnose Alzheimer’s?: Legal and ethical issues with at-home consumer devices

  • David A. Simon,
  • Barbara J. Evans,
  • Carmel Shachar,
  • I. Glenn Cohen
First published:July 25, 2022
Voice-based AI-powered digital assistants, such as Alexa, Siri, and Google Assistant, present an exciting opportunity to translate healthcare from the hospital to the home. But building a digital, medical panopticon can raise many legal and ethical challenges if not designed and implemented thoughtfully. This paper highlights the benefits and explores the challenges of using digital assistants to detect early signs of cognitive impairment, focusing on issues such as consent, bycatching, privacy, and regulatory oversight. By using a fictional but plausible near-future hypothetical, we demonstrate why an “ethics-by-design” approach is necessary for consumer-monitoring tools that may be used to identify health concerns for their users.