Cell Stem Cell
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New articles

Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

September 15, 2022


Vaccination-based immunotherapy to target profibrotic cells in liver and lung

  • Michal Sobecki,
  • Jing Chen,
  • Ewelina Krzywinska,
  • Shunmugam Nagarajan,
  • Zheng Fan,
  • Eric Nelius,
  • Josep M. Monné Rodriguez,
  • Frauke Seehusen,
  • Amro Hussein,
  • Greta Moschini,
  • Edries Y. Hajam,
  • Ravi Kiran,
  • Dagmar Gotthardt,
  • Julien Debbache,
  • Cécile Badoual,
  • Tatsuyuki Sato,
  • Takayuki Isagawa,
  • Norihiko Takeda,
  • Corinne Tanchot,
  • Eric Tartour,
  • Achim Weber,
  • Sabine Werner,
  • Johannes Loffing,
  • Lukas Sommer,
  • Veronika Sexl,
  • Christian Münz,
  • Carol Feghali-Bostwick,
  • Elena Pachera,
  • Oliver Distler,
  • Jess Snedeker,
  • Colin Jamora,
  • Christian Stockmann
First published:September 15, 2022
Open Access
Fibrosis accounts for up to 45% of all deaths in the developed world. Stockmann and colleagues present a vaccination approach to ablate activated fibroblasts and ameliorate fibrosis in the liver and lungs without disturbing tissue homeostasis. These results provide a rationale for vaccination-based immunotherapies to treat fibrosis.

September 8, 2022


Mouse embryo model derived exclusively from embryonic stem cells undergoes neurulation and heart development

  • Kasey Y.C. Lau,
  • Hernan Rubinstein,
  • Carlos W. Gantner,
  • Ron Hadas,
  • Gianluca Amadei,
  • Yonatan Stelzer,
  • Magdalena Zernicka-Goetz
First published:September 08, 2022
Open Access
Lau and colleagues generated an in vitro mouse embryo model with embryonic and extraembryonic lineages using exclusively embryonic stem cells and showed that the embryoids can undergo advanced development to late headfold stages. Single-cell RNA sequencing demonstrates similarity between embryoids and natural mouse embryos.