Aug 24, 2017
Volume 170Issue 5p817-1044
Open Archive
On the cover: Glioma invasion of the lateral ventricle subventricular zone (SVZ),
a neural stem/precursor cell niche, is a frequent and clinically consequential event
complicating the course of pediatric and adult high-grade gliomas. In this issue,
Qin et al. (845–859) demonstrate that high-grade glioma invasion of the SVZ is mediated
by release of pleiotrophin (PTN) from neural precursor cells (NPCs). PTN, in complex
with the chaperone protein HSP90 and adapter proteins SPARC/SPARCL1, acts as a chemoattractant
to which glioma cells home. The image illustrates the lateral ventricle as a lake
and normal neural precursor cells as people barbecuing on the beach (the SVZ) with
a brain landscape in the background. NPC activities on the SVZ “beach” generate signals
(smoke) that attract invading glioma cells depicted as monsters. Artwork by Rob Dobi....Show more
On the cover: Glioma invasion of the lateral ventricle subventricular zone (SVZ),
a neural stem/precursor cell niche, is a frequent and clinically consequential event
complicating the course of pediatric and adult high-grade gliomas. In this issue,
Qin et al. (845–859) demonstrate that high-grade glioma invasion of the SVZ is mediated
by release of pleiotrophin (PTN) from neural precursor cells (NPCs). PTN, in complex
with the chaperone protein HSP90 and adapter proteins SPARC/SPARCL1, acts as a chemoattractant
to which glioma cells home. The image illustrates the lateral ventricle as a lake
and normal neural precursor cells as people barbecuing on the beach (the SVZ) with
a brain landscape in the background. NPC activities on the SVZ “beach” generate signals
(smoke) that attract invading glioma cells depicted as monsters. Artwork by Rob Dobi.
