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Cell
This journal offers authors two options (open access or subscription) to publish research

Aug 24, 2017

Volume 170Issue 5p817-1044
Open Archive
On the cover: Glioma invasion of the lateral ventricle subventricular zone (SVZ), a neural stem/precursor cell niche, is a frequent and clinically consequential event complicating the course of pediatric and adult high-grade gliomas. In this issue, Qin et al. (845–859) demonstrate that high-grade glioma invasion of the SVZ is mediated by release of pleiotrophin (PTN) from neural precursor cells (NPCs). PTN, in complex with the chaperone protein HSP90 and adapter proteins SPARC/SPARCL1, acts as a chemoattractant to which glioma cells home. The image illustrates the lateral ventricle as a lake and normal neural precursor cells as people barbecuing on the beach (the SVZ) with a brain landscape in the background. NPC activities on the SVZ “beach” generate signals (smoke) that attract invading glioma cells depicted as monsters. Artwork by Rob Dobi....
On the cover: Glioma invasion of the lateral ventricle subventricular zone (SVZ), a neural stem/precursor cell niche, is a frequent and clinically consequential event complicating the course of pediatric and adult high-grade gliomas. In this issue, Qin et al. (845–859) demonstrate that high-grade glioma invasion of the SVZ is mediated by release of pleiotrophin (PTN) from neural precursor cells (NPCs). PTN, in complex with the chaperone protein HSP90 and adapter proteins SPARC/SPARCL1, acts as a chemoattractant to which glioma cells home. The image illustrates the lateral ventricle as a lake and normal neural precursor cells as people barbecuing on the beach (the SVZ) with a brain landscape in the background. NPC activities on the SVZ “beach” generate signals (smoke) that attract invading glioma cells depicted as monsters. Artwork by Rob Dobi.

Leading Edge

Select

  • Cultivating Beauty and Good Taste

    • Sarah Geisler
    Imagine a world where desirable traits are easily programmable. Farmers can select to grow plant varieties that both surprise and delight even the most sophisticated taste buds. Nutrient content and crop yields are improved to fight hunger and malnutrition in vulnerable populations. Vibrant floral varieties can be grown in your home garden that not only exhibit optimized fragrance profiles, but also emit their lovely aromas in robust and conveniently timed bursts. With modern plant genomics offering unprecedented access to the genetic basis of phenotypes and with gene editing technologies allowing precision modulation, such a far-fetched, sci-fi reality might actually be within foreseeable reach.

Previews

  • The Tropism of Pleiotrophin: Orchestrating Glioma Brain Invasion

    • David H. Gutmann
    The lateral ventricle (LV) is a preferential location for brain tumor spread; however, the instructive cues responsible for this unique tropism were previously unknown. In this issue, Qin et al. elucidate the underlying mechanism, demonstrating that LV-neural progenitors secrete a pleiotrophin (PTN)-containing complex, which attracts glioma cells through ROCK/Rho activation.
  • Reprogramming Enhancers to Drive Metastasis

    • Raul Mostoslavsky,
    • Nabeel Bardeesy
    Acquired molecular changes can promote the spreading of primary tumor cells to distant tissues. In this issue of Cell, Roe et al. show that metastatic progression of pancreatic cancer involves large-scale enhancer reprogramming by Foxa1, which activates transcriptional program specifying early endodermal stem cells.
  • Cancer Evolution Constrained by the Immune Microenvironment

    • Nicholas McGranahan,
    • Charles Swanton
    Tumor development is a Darwinian evolutionary process, involving the interplay between cancer subclones and the local immune microenvironment. These complex interactions are highlighted in this issue of Cell by the results from Jiménez-Sánchez et al. of a deep analysis of one patient with advanced serous carcinoma of the ovary.

Review

  • High-Definition Medicine

    • Ali Torkamani,
    • Kristian G. Andersen,
    • Steven R. Steinhubl,
    • Eric J. Topol
    The foundation for a new era of data-driven medicine has been set by recent technological advances that enable the assessment and management of human health at an unprecedented level of resolution—what is referred to as high-definition medicine.

Articles

Resource

  • In Situ Capture of Chromatin Interactions by Biotinylated dCas9

    • Xin Liu,
    • Yuannyu Zhang,
    • Yong Chen,
    • Mushan Li,
    • Feng Zhou,
    • Kailong Li,
    • Hui Cao,
    • Min Ni,
    • Yuxuan Liu,
    • Zhimin Gu,
    • Kathryn E. Dickerson,
    • Shiqi Xie,
    • Gary C. Hon,
    • Zhenyu Xuan,
    • Michael Q. Zhang,
    • Zhen Shao,
    • Jian Xu
    A biotinylated dCas9-based method for simultaneously studying long-range DNA interactions and chromatin-associated proteins at any genomic location.

SnapShot

  • SnapShot: Cellular Senescence in Pathophysiology

    • Ricardo Iván Martínez-Zamudio,
    • Lucas Robinson,
    • Pierre-François Roux,
    • Oliver Bischof
    Cellular senescence is a fundamental cell fate, important both in physiological and pathophysiological processes. This SnapShot focuses on the role of cellular senescence in health, disease, and aging.
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