This journal offers authors two options (open access or subscription) to publish research

Oct 29, 2020

Volume 183Issue 3p555-838
Open Archive
On the cover: The octopus uses its long, flexible arms to explore the seafloor for hidden prey. In this issue, van Giesen et al. (594–604) investigate this unique “taste by touch” sense to reveal that the octopus uses specialized chemotactile receptors to detect poorly soluble natural molecules and transmit specific signals among its distributed nervous system. The cover art shows Octopus bimaculoides exploring a coffee cup in its home tank. Image credit: Lena van Giesen....
On the cover: The octopus uses its long, flexible arms to explore the seafloor for hidden prey. In this issue, van Giesen et al. (594–604) investigate this unique “taste by touch” sense to reveal that the octopus uses specialized chemotactile receptors to detect poorly soluble natural molecules and transmit specific signals among its distributed nervous system. The cover art shows Octopus bimaculoides exploring a coffee cup in its home tank. Image credit: Lena van Giesen.

Leading Edge



  • Black in Nature

    • Peter Soroye,
    • Kennda Lynch,
    • Tatenda Dalu,
    • Jessica Ware,
    • Alex Troutman,
    • Aviwe Matiwane,
    • Angelica Patterson
    The uplifting Twitter trend #BlackInNature highlights the stories of Black people in the outdoors, many of whom are life scientists who perform research in the field. We asked #BlackInNature scientists to share their experiences and motivations to get outside.
  • On Being Black in the Ivory Tower

    • Alissa Armstrong,
    • Jeremy Lomax,
    • Nikki Traylor-Knowles,
    • Ascel Samba-Louaka,
    • Christina Towers
    When I went on the job market, I tried to refine the list of positions to which I applied by assessing the racial and ethnic make-up of the faculty. This was a wishful exercise because most faculty were white and only a handful had even one Black faculty member. In retrospect, it should have been unsurprising, given that I was used to being the only, or one of a few, starting with my math and science interest in elementary school and persisting throughout my academic and professional career. However, I hope that my presence as a faculty member as well as the recruitment and retention activities I participate in change this experience for prospective Black faculty.
  • Mentoring to Foster a Diverse Future

    • Mélise Edwards,
    • Michael D.L. Johnson,
    • Robert W. Fernandez,
    • Beronda L. Montgomery,
    • Adewunmi Adelaja,
    • Tomi Akingbade
    Diversity is foundational for the fruition of technological advancement and scientific discovery. A diverse body of researchers is essential to tackle STEM in ways we cannot fully explore with a homogeneous workforce. Moreover, the lack of visible representation can often dissuade underrepresented students from pursuing careers in STEM. What sort of messages might someone subconsciously process when they see a homogeneous makeup of classes, scientists featured on presentations, lab personnel, or entire graduate programs?


  • To See a Face Like Mine

    • Esther A. Odekunle
    As an underrepresented scientist navigating her way through the field, I have either noticed or experienced barriers at key stages in the scientific journey that hinder the representation and visibility of diverse people in the community. To see a face like mine represented in science requires intentional action to turn a system not initially built to include all into a community that reflects, embraces, and celebrates people from all demographics.
  • Patching the Leaks: Revitalizing and Reimagining the STEM Pipeline

    • Antentor O. Hinton Jr.,
    • Christina M. Termini,
    • Elsie C. Spencer,
    • Florentine U.N. Rutaganira,
    • Daphney Chery,
    • ReAna Roby,
    • Zer Vue,
    • Angela D. Pack,
    • Lillian J. Brady,
    • Edgar Garza-Lopez,
    • Andrea G. Marshall,
    • Samantha C. Lewis,
    • Haysetta D. Shuler,
    • Brittany L. Taylor,
    • Melanie R. McReynolds,
    • Caroline B. Palavicino-Maggio
    We identify problematic areas throughout the Science, Technology, Engineering and Mathematics (STEM) pipeline that perpetuate racial disparities in academia. Distinct ways to curtail these disparities include early exposure and access to resources, supportive mentoring networks and comprehensive training programs specifically for racially minoritized students and trainees at each career stage. These actions will revitalize the STEM pipeline.
  • Revising the a Priori Hypothesis: Systemic Racism Has Penetrated Scientific Funding

    • Kafui Dzirasa
    To manifest our sincerest aspirations to “enhance health, lengthen life, and reduce illness and disability,” the US biomedical research enterprise must directly confront the reality of structural racism in scientific funding and the widespread denial of its existence. I believe that moment in American history has, at long last, arrived. Black Americans have experienced disproportional morbidity and mortality from COVID19, exposing the tawdry underbelly of an American health enterprise that was reared to conceptualize blacks as 3/5ths of a person. Rather than extending Hippocrates’ dearly held promise to first do no harm, our nation’s medical system was seeded with this insidious notion of sub-humanity, facilitating the devaluation of black lives for the potential for scientific and clinical progress. Two centuries later, this persistent bias continues to infect our health care delivery systems. The heinous acts of Dr. J. Marion Sims, who performed gynecological surgical experiments on unanesthetized enslaved women to develop and perfect his clinical procedures, still echo in the unfounded belief that blacks have a higher pain tolerance and the striking incidence of maternal mortality in black women. The unethical Tuskegee study in which medical treatment was withheld from black men to evaluate the course of syphilis still echoes in the reflexive under participation of blacks in clinical trials for potential medical therapeutics.
  • Not All Champions Are Allies in Health Disparities Research

    • Leanne Woods-Burnham
    Responsible health-disparities research requires a multifaceted approach to address genetic, biological, socioeconomic, and lifestyle contributors to disease. For researchers dedicated to the cause, thorough experimental standards at the bench, in the clinic, and within the community must prioritize adequate representation and cultural competency. Not everyone is up for the challenge.
  • Starting Conversations toward Inclusion

    • Faith Karanja,
    • Raegan R. Bostic,
    • Danielle DaCrema,
    • Gustavo G. Pacheco
    Communal discussions on anti-racism and inclusion are crucial to addressing the history of racism in scientific communities. Unfortunately, universities are not universally implementing these conversations. We provide a blueprint for initiating and executing student-led discussions to empower young scientists to take action toward making science more welcoming and inclusive.


  • A Sucker for Taste

    • Rebecca D. Tarvin
    Biology is entering a new era in which techniques honed in model systems can be applied to the expanding array of organisms with sequenced genomes. In this issue of Cell, van Giesen et al. (2020) characterize the molecular foundation of the touch-taste sensory system in octopus suckers.
  • When Gut Microbiota Creep into Fat, the Fat Creeps Back

    • Sean P. Spencer,
    • Justin L. Sonnenburg
    Ha and colleagues describe a previously unappreciated diversity of microbes in the mesenteric adipose tissue (MAT) surrounding the GI tract. Viable bacteria that are mislocalized from the gut microbiota and metabolically adapted to the MAT contribute to the “creeping fat” of Crohn’s disease.
  • Strength in Numbers: Identifying Neoantigen Targets for Cancer Immunotherapy

    • Rigel J. Kishton,
    • Rachel C. Lynn,
    • Nicholas P. Restifo
    Targeting cancer neoantigens generated by tumor-exclusive somatic mutations is an attractive yet challenging strategy for the robust and specific elimination of tumor cells by cellular immunotherapy. In this issue of Cell, Wells et al. describe a consortium-based approach to optimize bioinformatics pipelines to sensitively and accurately predict immunogenic neoantigens from next-generation sequencing data.


  • Molecular Basis of Chemotactile Sensation in Octopus

    • Lena van Giesen,
    • Peter B. Kilian,
    • Corey A.H. Allard,
    • Nicholas W. Bellono
    The peripherally distributed octopus nervous system exhibits exceptional signal filtering properties that are mediated by highly specialized, chemotactile sensory receptors that control touch-taste arm behavior.
  • An Amygdala Circuit Mediates Experience-Dependent Momentary Arrests during Exploration

    • Paolo Botta,
    • Akira Fushiki,
    • Ana Mafalda Vicente,
    • Luke A. Hammond,
    • Alice C. Mosberger,
    • Charles R. Gerfen,
    • Darcy Peterka,
    • Rui M. Costa
    A genetically and projection-defined basolateral amygdala circuit mediates momentary arrests during exploration that emerge in an experience-dependent manner when mice familiarize themselves with a novel environment.
  • The Statistical Structure of the Hippocampal Code for Space as a Function of Time, Context, and Value

    • Jae Sung Lee,
    • John J. Briguglio,
    • Jeremy D. Cohen,
    • Sandro Romani,
    • Albert K. Lee
    A unified response pattern of hippocampal place cells, driven by individual cell-intrinsic mechanisms, quantitatively predicts the structure of representation of space at the population level across varying conditions by the hippocampus in mice.
  • TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

    • Chien-Hsiung Yu,
    • Sophia Davidson,
    • Cassandra R. Harapas,
    • James B. Hilton,
    • Michael J. Mlodzianoski,
    • Pawat Laohamonthonkul,
    • Cynthia Louis,
    • Ronnie Ren Jie Low,
    • Jonas Moecking,
    • Dominic De Nardo,
    • Katherine R. Balka,
    • Dale J. Calleja,
    • Fiona Moghaddas,
    • Erya Ni,
    • Catriona A. McLean,
    • Andre L. Samson,
    • Shiraz Tyebji,
    • Christopher J. Tonkin,
    • Christopher R. Bye,
    • Bradley J. Turner,
    • Genevieve Pepin,
    • Michael P. Gantier,
    • Kelly L. Rogers,
    • Kate McArthur,
    • Peter J. Crouch,
    • Seth L. Masters
    TDP-43 causes inflammation in ALS by stimulating mitochondrial DNA release, which is subsequently sensed by the cytosolic cGAS/STING pathway, suggesting that inhibition of cGAS/STING could help alleviate inflammation-related damage in ALS.
  • Endocannabinoids Inhibit the Induction of Virulence in Enteric Pathogens

    • Melissa Ellermann,
    • Alline R. Pacheco,
    • Angel G. Jimenez,
    • Regan M. Russell,
    • Santiago Cuesta,
    • Aman Kumar,
    • Wenhan Zhu,
    • Gonçalo Vale,
    • Sarah A. Martin,
    • Prithvi Raj,
    • Jeffrey G. McDonald,
    • Sebastian E. Winter,
    • Vanessa Sperandio
    The endocannabinoid hormone 2-AG protects mice from enteric bacterial infection via inhibition of pathogen virulence programs, resulting in reduced pathogen burden and attenuated colitis in mice with increased 2-AG levels.
  • Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans

    • Connie W.Y. Ha,
    • Anthony Martin,
    • Gregory D. Sepich-Poore,
    • Baochen Shi,
    • Yizhou Wang,
    • Kenneth Gouin,
    • Gregory Humphrey,
    • Karenina Sanders,
    • Yasiru Ratnayake,
    • Kelvin S.L. Chan,
    • Gustaf Hendrick,
    • J.R. Caldera,
    • Christian Arias,
    • Jacob E. Moskowitz,
    • Shannan J. Ho Sui,
    • Shaohong Yang,
    • David Underhill,
    • Matthew J. Brady,
    • Simon Knott,
    • Kelly Kaihara,
    • Michael J. Steinbaugh,
    • Huiying Li,
    • Dermot P.B. McGovern,
    • Rob Knight,
    • Phillip Fleshner,
    • Suzanne Devkota
    Ha et al. provide evidence that, in humans with inflammatory bowel disease, the phenomenon known as “creeping fat” is a protective response where mesenteric adipose tissue migrates (or “creeps”) to sites of gut barrier dysfunction to prevent systemic dissemination of potentially harmful bacterial antigens that have translocated across the barrier from the gut lumen.
  • A MicroRNA Linking Human Positive Selection and Metabolic Disorders

    • Lifeng Wang,
    • Nasa Sinnott-Armstrong,
    • Alexandre Wagschal,
    • Abigail R. Wark,
    • Joao-Paulo Camporez,
    • Rachel J. Perry,
    • Fei Ji,
    • Yoojin Sohn,
    • Justin Oh,
    • Su Wu,
    • Jessica Chery,
    • Bahareh Nemati Moud,
    • Alham Saadat,
    • Simon N. Dankel,
    • Gunnar Mellgren,
    • Divya Sri Priyanka Tallapragada,
    • Sophie Madlen Strobel,
    • Mi-Jeong Lee,
    • Ryan Tewhey,
    • Pardis C. Sabeti,
    • Anne Schaefer,
    • Andreas Petri,
    • Sakari Kauppinen,
    • Raymond T. Chung,
    • Alexander Soukas,
    • Joseph Avruch,
    • Susan K. Fried,
    • Hans Hauner,
    • Ruslan I. Sadreyev,
    • Gerald I. Shulman,
    • Melina Claussnitzer,
    • Anders M. Näär
    A positively selected locus linked to ancient adaptation to milk consumption is also linked to metabolic disorders and contains a microRNA that controls energy expenditure, potentially connecting these two phenotypes and the role of selection in metabolic disease.
  • Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages

    • Jeremy Lotto,
    • Sibyl Drissler,
    • Rebecca Cullum,
    • Wei Wei,
    • Manu Setty,
    • Erin M. Bell,
    • Stéphane C. Boutet,
    • Sonja Nowotschin,
    • Ying-Yi Kuo,
    • Vidur Garg,
    • Dana Pe’er,
    • Deanna M. Church,
    • Anna-Katerina Hadjantonakis,
    • Pamela A. Hoodless
    A comprehensive atlas of mouse liver emergence is described at single-cell resolution starting at endoderm progenitor specification, including data detailing divergence of vascular and sinusoidal endothelia, hepatoblast specification, and the emergence of a distinct, migratory hepatomesenchymal cell type.
  • Assembly Mechanism of Mucin and von Willebrand Factor Polymers

    • Gabriel Javitt,
    • Lev Khmelnitsky,
    • Lis Albert,
    • Lavi Shlomo Bigman,
    • Nadav Elad,
    • David Morgenstern,
    • Tal Ilani,
    • Yaakov Levy,
    • Ron Diskin,
    • Deborah Fass
    Javitt et al. describe molecularly how mucin glycoproteins and von Willebrand factor—complex macromolecules responsible for mucociliary clearance in the lung, the intestinal mucosal barrier, and blood clotting—use a shared mechanism to form polymers and hydrogels that protect the respiratory tract, intestinal tract, and vasculature.
  • Molecular Architecture of the SARS-CoV-2 Virus

    • Hangping Yao,
    • Yutong Song,
    • Yong Chen,
    • Nanping Wu,
    • Jialu Xu,
    • Chujie Sun,
    • Jiaxing Zhang,
    • Tianhao Weng,
    • Zheyuan Zhang,
    • Zhigang Wu,
    • Linfang Cheng,
    • Danrong Shi,
    • Xiangyun Lu,
    • Jianlin Lei,
    • Max Crispin,
    • Yigong Shi,
    • Lanjuan Li,
    • Sai Li
    Combined imaging analyses of 2,294 intact virions from the authentic SARS-CoV-2 virus resolve the S protein in pre- and postfusion conformations and characterize the molecular architecture of SARS-CoV-2 at high resolution.
  • Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant

    • Leonid Yurkovetskiy,
    • Xue Wang,
    • Kristen E. Pascal,
    • Christopher Tomkins-Tinch,
    • Thomas P. Nyalile,
    • Yetao Wang,
    • Alina Baum,
    • William E. Diehl,
    • Ann Dauphin,
    • Claudia Carbone,
    • Kristen Veinotte,
    • Shawn B. Egri,
    • Stephen F. Schaffner,
    • Jacob E. Lemieux,
    • James B. Munro,
    • Ashique Rafique,
    • Abhi Barve,
    • Pardis C. Sabeti,
    • Christos A. Kyratsous,
    • Natalya V. Dudkina,
    • Kuang Shen,
    • Jeremy Luban
    Structural and molecular insights into the SARS-CoV-2 spike protein variant D614G reveal the basis of its increased infectivity
  • M. tuberculosis Reprograms Hematopoietic Stem Cells to Limit Myelopoiesis and Impair Trained Immunity

    • Nargis Khan,
    • Jeffrey Downey,
    • Joaquin Sanz,
    • Eva Kaufmann,
    • Birte Blankenhaus,
    • Alain Pacis,
    • Erwan Pernet,
    • Eisha Ahmed,
    • Silvia Cardoso,
    • Anastasia Nijnik,
    • Bruce Mazer,
    • Christopher Sassetti,
    • Marcel A. Behr,
    • Miguel P. Soares,
    • Luis B. Barreiro,
    • Maziar Divangahi
    The pathogen Mycobacterium tuberculosis reprograms hematopoietic stem cells and limits myelopoiesis while impairing trained immunity responses via a type I IFN/iron signaling axis.
  • Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

    • Lydia Kalafati,
    • Ioannis Kourtzelis,
    • Jonas Schulte-Schrepping,
    • Xiaofei Li,
    • Aikaterini Hatzioannou,
    • Tatyana Grinenko,
    • Eman Hagag,
    • Anupam Sinha,
    • Canan Has,
    • Sevina Dietz,
    • Antonio Miguel de Jesus Domingues,
    • Marina Nati,
    • Sundary Sormendi,
    • Ales Neuwirth,
    • Antonios Chatzigeorgiou,
    • Athanasios Ziogas,
    • Mathias Lesche,
    • Andreas Dahl,
    • Ian Henry,
    • Pallavi Subramanian,
    • Ben Wielockx,
    • Peter Murray,
    • Peter Mirtschink,
    • Kyoung-Jin Chung,
    • Joachim L. Schultze,
    • Mihai G. Netea,
    • George Hajishengallis,
    • Panayotis Verginis,
    • Ioannis Mitroulis,
    • Triantafyllos Chavakis
    Pre-treatment of mice with β-glucan, an agonist of trained immunity responses, leads to epigenetic changes in granulopoiesis and neutrophil function to drive anti-tumor immune responses.
  • Trained Immunity-Promoting Nanobiologic Therapy Suppresses Tumor Growth and Potentiates Checkpoint Inhibition

    • Bram Priem,
    • Mandy M.T. van Leent,
    • Abraham J.P. Teunissen,
    • Alexandros Marios Sofias,
    • Vera P. Mourits,
    • Lisa Willemsen,
    • Emma D. Klein,
    • Roderick S. Oosterwijk,
    • Anu E. Meerwaldt,
    • Jazz Munitz,
    • Geoffrey Prévot,
    • Anna Vera Verschuur,
    • Sheqouia A. Nauta,
    • Esther M. van Leeuwen,
    • Elizabeth L. Fisher,
    • Karen A.M. de Jong,
    • Yiming Zhao,
    • Yohana C. Toner,
    • Georgios Soultanidis,
    • Claudia Calcagno,
    • Paul H.H. Bomans,
    • Heiner Friedrich,
    • Nico Sommerdijk,
    • Thomas Reiner,
    • Raphaël Duivenvoorden,
    • Eva Zupančič,
    • Julie S. Di Martino,
    • Ewelina Kluza,
    • Mohammad Rashidian,
    • Hidde L. Ploegh,
    • Rick M. Dijkhuizen,
    • Sjoerd Hak,
    • Carlos Pérez-Medina,
    • Jose Javier Bravo-Cordero,
    • Menno P.J. de Winther,
    • Leo A.B. Joosten,
    • Andrea van Elsas,
    • Zahi A. Fayad,
    • Alexander Rialdi,
    • Denis Torre,
    • Ernesto Guccione,
    • Jordi Ochando,
    • Mihai G. Netea,
    • Arjan W. Griffioen,
    • Willem J.M. Mulder
    A bone marrow targeted nanobiologic platform that is designed to elicit trained immunity responses has the ability to reduce tumor growth and augment immune checkpoint blockade.
  • A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms

    • Nazar Mashtalir,
    • Hiroshi Suzuki,
    • Daniel P. Farrell,
    • Akshay Sankar,
    • Jie Luo,
    • Martin Filipovski,
    • Andrew R. D’Avino,
    • Roodolph St. Pierre,
    • Alfredo M. Valencia,
    • Takashi Onikubo,
    • Robert G. Roeder,
    • Yan Han,
    • Yuan He,
    • Jeffrey A. Ranish,
    • Frank DiMaio,
    • Thomas Walz,
    • Cigall Kadoch
    Structural analysis of an endogenous human SWI/SNF complex shows how it engages with nucleosomes and provides insight into how cancer-associated mutations affect the remodeler’s function.


  • Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

    • Daniel K. Wells,
    • Marit M. van Buuren,
    • Kristen K. Dang,
    • Vanessa M. Hubbard-Lucey,
    • Kathleen C.F. Sheehan,
    • Katie M. Campbell,
    • Andrew Lamb,
    • Jeffrey P. Ward,
    • John Sidney,
    • Ana B. Blazquez,
    • Andrew J. Rech,
    • Jesse M. Zaretsky,
    • Begonya Comin-Anduix,
    • Alphonsus H.C. Ng,
    • William Chour,
    • Thomas V. Yu,
    • Hira Rizvi,
    • Jia M. Chen,
    • Patrice Manning,
    • Gabriela M. Steiner,
    • Xengie C. Doan,
    • The Tumor Neoantigen Selection Alliance,
    • Taha Merghoub,
    • Justin Guinney,
    • Adam Kolom,
    • Cheryl Selinsky,
    • Antoni Ribas,
    • Matthew D. Hellmann,
    • Nir Hacohen,
    • Alessandro Sette,
    • James R. Heath,
    • Nina Bhardwaj,
    • Fred Ramsdell,
    • Robert D. Schreiber,
    • Ton N. Schumacher,
    • Pia Kvistborg,
    • Nadine A. Defranoux
    Genomic tumor sequencing data with matched measurements of tumor epitope immunogenicity allows for insights into the governing parameters of epitope immunogenicity and generation of models for effective neoantigen prediction.