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Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

October 6, 2022


Intestinal mucin is a chaperone of multivalent copper

  • Nava Reznik,
  • Annastassia D. Gallo,
  • Katherine W. Rush,
  • Gabriel Javitt,
  • Yael Fridmann-Sirkis,
  • Tal Ilani,
  • Noa A. Nairner,
  • Simon Fishilevich,
  • David Gokhman,
  • Kelly N. Chacón,
  • Katherine J. Franz,
  • Deborah Fass
First published:October 06, 2022
Open Access
Mucins, the major constituents of mucus, protect cells by capturing copper and blocking generation of reactive oxygen species. A two-tiered site in intestinal mucin enables binding of copper in either of its common redox states, which may facilitate safe delivery to cells.

October 4, 2022


A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors

  • Liming Yan,
  • Yucen Huang,
  • Ji Ge,
  • Zhenyu Liu,
  • Pengchi Lu,
  • Bo Huang,
  • Shan Gao,
  • Junbo Wang,
  • Liping Tan,
  • Sihan Ye,
  • Fengxi Yu,
  • Weiqi Lan,
  • Shiya Xu,
  • Feng Zhou,
  • Lei Shi,
  • Luke W. Guddat,
  • Yan Gao,
  • Zihe Rao,
  • Zhiyong Lou
First published:October 04, 2022
Structural analyses reveal how proteins from SARS-CoV-2 cooperate and use GTP to form the cap on viral mRNA, and how this process is interrupted by nucleotide analogues that serve as antiviral drugs.

X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women

  • Yan Yan,
  • Xinming Wang,
  • Dale Chaput,
  • Min-Kyoo Shin,
  • Yeojung Koh,
  • Li Gan,
  • Andrew A. Pieper,
  • Jung-A.A. Woo,
  • David E. Kang
First published:October 04, 2022
For women, the risk of developing Alzheimer’s disease is significantly higher than for men. In this study, Yan et al. uncover a molecular mechanism underpinning the heightened susceptibility.

Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify autophagosome initiation sites

  • Qiaoxia Zheng,
  • Yong Chen,
  • Di Chen,
  • Hongyu Zhao,
  • Yun Feng,
  • Quan Meng,
  • Yan Zhao,
  • Hong Zhang
First published:October 04, 2022
Autophagy stimuli trigger Ca2+ transients/oscillations on the outer surface of the ER membrane, which induce phase separation of FIP200 for specification of autophagosome initiation sites on the ER. The metazoan-specific ER transmembrane autophagy protein EPG-4/EI24 controls the amplitude, frequency, and duration of the Ca2+ transient for autophagosome progression.

September 30, 2022

Featured Article

Primate hemorrhagic fever-causing arteriviruses are poised for spillover to humans

  • Cody J. Warren,
  • Shuiqing Yu,
  • Douglas K. Peters,
  • Arturo Barbachano-Guerrero,
  • Qing Yang,
  • Bridget L. Burris,
  • Gabriella Worwa,
  • I-Chueh Huang,
  • Gregory K. Wilkerson,
  • Tony L. Goldberg,
  • Jens H. Kuhn,
  • Sara L. Sawyer
First published:September 30, 2022
Arteriviruses that infect nonhuman primates can cause fatal hemorrhagic fevers. One such virus, SHFV, is capable of infecting and replicating in human monocytes by using CD163 as the intracellular receptor. This suggests that SHFV may not require major adaptations for the human host, and that surveillance is needed for this virus family.

September 28, 2022


The gripping story of integrins

  • James E. Rothman
First published:September 28, 2022
The foundational research recognized by this year’s Lasker Basic Science Research Award “for discoveries concerning the integrins—key mediators of cell-matrix and cell-cell adhesion in physiology and disease” reaches back to the 1970s.

Before you call the midwife

  • Laurie H. Glimcher,
  • Gregory A. Petsko
First published:September 28, 2022
The 2022 Lasker-DeBakey Clinical Medical Research Award is presented to Yuk Ming Dennis Lo of the Chinese University of Hong Kong for the discovery of fetal DNA in maternal blood, leading to development of noninvasive prenatal testing for Down syndrome.

The art and science of building castles in the sky and houses of cards that don’t collapse

  • Joseph L. Goldstein
First published:September 28, 2022
The creative process in art and science involves two phases—generating and exploring new and wild ideas (building castles in the sky) and then narrowing down and focusing on the most tractable and useful ones (building houses of cards that don’t topple over).

Expansion of the global RNA virome reveals diverse clades of bacteriophages

  • Uri Neri,
  • Yuri I. Wolf,
  • Simon Roux,
  • Antonio Pedro Camargo,
  • Benjamin Lee,
  • Darius Kazlauskas,
  • I. Min Chen,
  • Natalia Ivanova,
  • Lisa Zeigler Allen,
  • David Paez-Espino,
  • Donald A. Bryant,
  • Devaki Bhaya,
  • RNA Virus Discovery Consortium,
  • Mart Krupovic,
  • Valerian V. Dolja,
  • Nikos C. Kyrpides,
  • Eugene V. Koonin,
  • Uri Gophna
First published:September 28, 2022
Open Access
Analysis of viral RNA genomes from thousands of diverse ecosystems substantially expands the known diversity of RNA viruses and show that RNA bacteriophages account for a much greater fraction of the global RNA virome.

September 27, 2022


State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides

  • Shizhong A. Dai,
  • Qi Hu,
  • Rong Gao,
  • Emily E. Blythe,
  • Kouki K. Touhara,
  • Hayden Peacock,
  • Ziyang Zhang,
  • Mark von Zastrow,
  • Hiroaki Suga,
  • Kevan M. Shokat
First published:September 27, 2022
Open Access
Cell-permeable Gαs inhibitors regulate G protein signal transduction with high nucleotide-binding-state selectivity and class specificity.

September 26, 2022


Interval between prior SARS-CoV-2 infection and booster vaccination impacts magnitude and quality of antibody and B cell responses

  • Clarisa M. Buckner,
  • Lela Kardava,
  • Omar El Merhebi,
  • Sandeep R. Narpala,
  • Leonid Serebryannyy,
  • Bob C. Lin,
  • Wei Wang,
  • Xiaozhen Zhang,
  • Felipe Lopes de Assis,
  • Sophie E.M. Kelly,
  • I-Ting Teng,
  • Genevieve E. McCormack,
  • Lauren H. Praiss,
  • Catherine A. Seamon,
  • M. Ali Rai,
  • Heather Kalish,
  • Peter D. Kwong,
  • Michael A. Proschan,
  • Adrian B. McDermott,
  • Anthony S. Fauci,
  • Tae-Wook Chun,
  • Susan Moir
First published:September 26, 2022
For COVID-19 mRNA vaccines, immunization with a booster dose elicits robust antibody and B-cell responses that are further increased if a breakthrough infection occurs after vaccination. In contrast, when infection occurs prior to booster vaccination, antibody and B-cell responses are muted closer to the infection time and achieve better levels as the time interval between infection and vaccination increases.

Quorum-sensing- and type VI secretion-mediated spatiotemporal cell death drives genetic diversity in Vibrio cholerae

  • Ameya A. Mashruwala,
  • Boyang Qin,
  • Bonnie L. Bassler
First published:September 26, 2022
Open Access
Type VI secretion system-mediated cell death in Vibrio cholerae colonies occurs in two space- and time-differentiated phases that cause death along the colony rim and interior, respectively. Cell death at the colony rim is a consequence of kin-killing and is proposed to drive genetic diversity in nature and during disease.

ER stress transforms random olfactory receptor choice into axon targeting precision

  • Hani J. Shayya,
  • Jerome K. Kahiapo,
  • Rachel Duffié,
  • Katherine S. Lehmann,
  • Lisa Bashkirova,
  • Kevin Monahan,
  • Ryan P. Dalton,
  • Joanna Gao,
  • Song Jiao,
  • Ira Schieren,
  • Leonardo Belluscio,
  • Stavros Lomvardas
First published:September 26, 2022
Open Access
ER stress levels in olfactory sensory neurons are influenced by olfactory receptor protein sequences, which lead to distinct patterns of axon guidance gene expression and specific axon targeting to glomeruli.

September 23, 2022


Innate frequency-discrimination hyperacuity in Williams-Beuren syndrome mice

  • Christopher M. Davenport,
  • Brett J.W. Teubner,
  • Seung Baek Han,
  • Mary H. Patton,
  • Tae-Yeon Eom,
  • Dusan Garic,
  • Benjamin J. Lansdell,
  • Abbas Shirinifard,
  • Ti-Cheng Chang,
  • Jonathon Klein,
  • Shondra M. Pruett-Miller,
  • Jay A. Blundon,
  • Stanislav S. Zakharenko
First published:September 23, 2022
Williams-Beuren syndrome is a neurodevelopmental disorder that is also associated with spared or superior auditory abilities. This condition is caused by a downregulation of the neuropeptide receptor VIPR1, driven by Gtf2ird1 haploinsufficiency.

September 13, 2022


Virological characteristics of the SARS-CoV-2 Omicron BA.2 subvariants, including BA.4 and BA.5

  • Izumi Kimura,
  • Daichi Yamasoba,
  • Tomokazu Tamura,
  • Naganori Nao,
  • Tateki Suzuki,
  • Yoshitaka Oda,
  • Shuya Mitoma,
  • Jumpei Ito,
  • Hesham Nasser,
  • Jiri Zahradnik,
  • Keiya Uriu,
  • Shigeru Fujita,
  • Yusuke Kosugi,
  • Lei Wang,
  • Masumi Tsuda,
  • Mai Kishimoto,
  • Hayato Ito,
  • Rigel Suzuki,
  • Ryo Shimizu,
  • MST Monira Begum,
  • Kumiko Yoshimatsu,
  • Kanako Terakado Kimura,
  • Jiei Sasaki,
  • Kaori Sasaki-Tabata,
  • Yuki Yamamoto,
  • Tetsuharu Nagamoto,
  • Jun Kanamune,
  • Kouji Kobiyama,
  • Hiroyuki Asakura,
  • Mami Nagashima,
  • Kenji Sadamasu,
  • Kazuhisa Yoshimura,
  • Kotaro Shirakawa,
  • Akifumi Takaori-Kondo,
  • Jin Kuramochi,
  • Gideon Schreiber,
  • Ken J. Ishii,
  • The Genotype to Phenotype Japan (G2P-Japan) Consortium,
  • Takao Hashiguchi,
  • Terumasa Ikeda,
  • Akatsuki Saito,
  • Takasuke Fukuhara,
  • Shinya Tanaka,
  • Keita Matsuno,
  • Kei Sato
First published:September 13, 2022
The SARS-CoV-2 Omicron variants BA.4 and BA.5 are currently causing infections and COVID-19 morbidities worldwide. Compared with the earlier variant BA.2, BA.4/5 shows more efficient replication and is more fusogenic. Structural views as well as in vivo studies in hamsters explain the antibody evasion and increased pathogenicity of BA.4/5 over BA.2.

August 31, 2022


Deep mutational learning predicts ACE2 binding and antibody escape to combinatorial mutations in the SARS-CoV-2 receptor-binding domain

  • Joseph M. Taft,
  • Cédric R. Weber,
  • Beichen Gao,
  • Roy A. Ehling,
  • Jiami Han,
  • Lester Frei,
  • Sean W. Metcalfe,
  • Max D. Overath,
  • Alexander Yermanos,
  • William Kelton,
  • Sai T. Reddy
First published:August 31, 2022
Open Access
A machine-learning-guided, protein engineering method enables the prediction of how SARS-CoV-2 RBD combinatorial mutations will impact therapeutic antibody escape and ACE2 affinity. This method facilitates the identification of multisite mutations that are major drivers of antibody escape and the evaluation of neutralizing antibody efficacy on heavily mutated viral variants.