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Current Biology
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Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

October 5, 2022

Report

Condensation of the fusion focus by the intrinsically disordered region of the formin Fus1 is essential for cell-cell fusion

  • Ingrid Billault-Chaumartin,
  • Olivia Muriel,
  • Laetitia Michon,
  • Sophie G. Martin
First published:October 05, 2022
Open Access
Different formin-family nucleators assemble actin networks with distinct architectures. Billault-Chaumartin et al. show that the condensation of the actin focus, which concentrates secretory vesicles for yeast gamete fusion, requires an intrinsically disordered region in the formin Fus1, which can be replaced by heterologous condensate-forming domains.

October 4, 2022

Article

Evidence for the recruitment of florivorous plant bugs as pollinators

  • Florian Etl,
  • Christian Kaiser,
  • Oliver Reiser,
  • Mario Schubert,
  • Stefan Dötterl,
  • Jürg Schönenberger
First published:October 04, 2022
Open Access
Etl et al. present a specialized angiosperm-plant bug (Heteroptera: Miridae) pollination system and identify the floral traits (e.g., thermogenesis, flower scent, and floral and pollen morphologies) that mediate the transition from florivory to a pollination mutualism.

October 3, 2022

Article

Orbitofrontal cortex populations are differentially recruited to support actions

  • Christian Cazares,
  • Drew C. Schreiner,
  • Mariela Lopez Valencia,
  • Christina M. Gremel
First published:October 03, 2022
Open Access
Cazares et al. show that lateral OFC is necessary for action-related information used in decision-making. Actions are differentially represented by the activity of distinct lOFC populations, with activity perturbations preventing the encoding, but not use, of prior action information. lOFC lesions recruit compensatory repetitive action control.

September 30, 2022

Report

The population genomic legacy of the second plague pandemic

  • Shyam Gopalakrishnan,
  • S. Sunna Ebenesersdóttir,
  • Inge K.C. Lundstrøm,
  • Gordon Turner-Walker,
  • Kristjan H.S. Moore,
  • Pierre Luisi,
  • Ashot Margaryan,
  • Michael D. Martin,
  • Martin Rene Ellegaard,
  • Ólafur þ. Magnússon,
  • Ásgeir Sigurðsson,
  • Steinunn Snorradóttir,
  • Droplaug N. Magnúsdóttir,
  • Jason E. Laffoon,
  • Lucy van Dorp,
  • Xiaodong Liu,
  • Ida Moltke,
  • María C. Ávila-Arcos,
  • Joshua G. Schraiber,
  • Simon Rasmussen,
  • David Juan,
  • Pere Gelabert,
  • Toni de-Dios,
  • Anna K. Fotakis,
  • Miren Iraeta-Orbegozo,
  • Åshild J. Vågene,
  • Sean Dexter Denham,
  • Axel Christophersen,
  • Hans K. Stenøien,
  • Filipe G. Vieira,
  • Shanlin Liu,
  • Torsten Günther,
  • Toomas Kivisild,
  • Ole Georg Moseng,
  • Birgitte Skar,
  • Christina Cheung,
  • Marcela Sandoval-Velasco,
  • Nathan Wales,
  • Hannes Schroeder,
  • Paula F. Campos,
  • Valdís B. Guðmundsdóttir,
  • Thomas Sicheritz-Ponten,
  • Bent Petersen,
  • Jostein Halgunset,
  • Edmund Gilbert,
  • Gianpiero L. Cavalleri,
  • Eivind Hovig,
  • Ingrid Kockum,
  • Tomas Olsson,
  • Lars Alfredsson,
  • Thomas F. Hansen,
  • Thomas Werge,
  • Eske Willerslev,
  • Francois Balloux,
  • Tomas Marques-Bonet,
  • Carles Lalueza-Fox,
  • Rasmus Nielsen,
  • Kári Stefánsson,
  • Agnar Helgason,
  • M. Thomas P. Gilbert
First published:September 30, 2022
Open Access
Gopalakrishnan et al. investigate the genomic signatures of the second plague pandemic on the residents of Trondheim in Norway. They find that the pandemic resulted in a sharp reduction in Gaelic ancestry and also find evidence of differential reference bias among their ancient samples, which reduces the reliability of selection analyses.
Article

Hypothalamic AgRP neurons exert top-down control on systemic TNF-α release during endotoxemia

  • Mehdi Boutagouga Boudjadja,
  • Isabella Culotta,
  • Gabriela C. De Paula,
  • Erika Harno,
  • Jenna Hunter,
  • João Paulo Cavalcanti-de-Albuquerque,
  • Simon M. Luckman,
  • Matthew Hepworth,
  • Anne White,
  • Gabriella Aviello,
  • Giuseppe D’Agostino
First published:September 30, 2022
Open Access
Boutagouga Boudjadja et al. find that fasting-responsive hypothalamic neurons have immunoregulatory functions—an indication that the immunomodulatory effects of fasting and negative energy balance could be mediated, at least in part, by a brain-initiated response and are not completely dependent on nutrient availability per se.
Article

Extrasynaptic signaling enables an asymmetric juvenile motor circuit to produce symmetric undulation

  • Yangning Lu,
  • Tosif Ahamed,
  • Ben Mulcahy,
  • Jun Meng,
  • Daniel Witvliet,
  • Sihui Asuka Guan,
  • Douglas Holmyard,
  • Wesley Hung,
  • Quan Wen,
  • Andrew D. Chisholm,
  • Aravinthan D.T. Samuel,
  • Mei Zhen
First published:September 30, 2022
A newborn worm's motor circuit is asymmetric, wired to only make dorsal bends. However, they make dorsoventral undulations. Lu et al. show that ventral bends happen by a tonic potentiation of ventral muscles by cholinergic premotor interneurons and anti-phasic entrainment to the dorsal bends.

September 29, 2022

Article

Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors

  • Yan Cao,
  • Diego Fajardo,
  • Debbie Guerrero-Given,
  • Melanie A. Samuel,
  • Toshihisa Ohtsuka,
  • Shannon E. Boye,
  • Naomi Kamasawa,
  • Kirill A. Martemyanov
First published:September 29, 2022
Cao et al. examine the mechanisms that govern post-developmental connectivity of rod photoreceptors into the retinal circuitry. This study reports that rod synapse formation can be restored in adult mice, enabling their rod-mediated vision at the behavioral level.

September 28, 2022

Article

Opto-katanin, an optogenetic tool for localized, microtubule disassembly

  • Joyce C.M. Meiring,
  • Ilya Grigoriev,
  • Wilco Nijenhuis,
  • Lukas C. Kapitein,
  • Anna Akhmanova
First published:September 28, 2022
Open Access
Meiring et al. engineer an optogenetic tool for fast, reversible, and highly localized disassembly of microtubules and maintenance of microtubule-free areas in cells by controlling the recruitment of katanin. This tool was used to study microtubule-dependent ER and cargo dynamics and to show that microtubule bundles can exert forces on the nucleus.

September 27, 2022

Report

A Cambrian tommotiid preserving soft tissues reveals the metameric ancestry of lophophorates

  • Jin Guo,
  • Luke A. Parry,
  • Jakob Vinther,
  • Gregory D. Edgecombe,
  • Fan Wei,
  • Jun Zhao,
  • Yang Zhao,
  • Olivier Béthoux,
  • Xiangtong Lei,
  • Ailin Chen,
  • Xianguang Hou,
  • Taimin Chen,
  • Peiyun Cong
First published:September 27, 2022
Open Access
Guo et al. describe the first known articulated camenellan tommotiid, a group of enigmatic Cambrian animals that have been difficult to classify based on disarticulated microfossils. Camenellans were vagile armored worms, with affinities to living lophophorates (e.g., brachiopods), suggesting a motile last common ancestor.

September 26, 2022

Report

Mating pair drives aggressive behavior in female Drosophila

  • Miguel Gaspar,
  • Sophie Dias,
  • Maria Luísa Vasconcelos
First published:September 26, 2022
Open Access
Gaspar et al. uncover a new context of female Drosophila melanogaster aggression. They find that, in this context, the willingness of the female to mate correlates with aggression. Aggression only occurs in the presence of food odor plus a mating pair, but the ability to smell conspecifics is important to modulate it.

September 23, 2022

Report

Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration

  • Carey Y.L. Huh,
  • Henri Leinonen,
  • Taylor Nakayama,
  • Julia R. Tomasello,
  • Jianye Zhang,
  • Jack Zeitoun,
  • John P. Peach,
  • Maximilian Halabi,
  • Jianying Z. Kiser,
  • Krzysztof Palczewski,
  • Philip D. Kiser,
  • Sunil P. Gandhi
First published:September 23, 2022
Open Access
Huh et al. report that a mouse model of retinal degeneration can undergo a significant restoration of vision when treated with retinoid therapy. Several visual properties in V1 are fully restored even when the therapy is started in adulthood, showcasing the potential of retinoid compounds as promising therapeutics for treating retinal diseases.

September 22, 2022

Article

Tracking widespread climate-driven change on temperate and tropical reefs

  • Rick D. Stuart-Smith,
  • Graham J. Edgar,
  • Ella Clausius,
  • Elizabeth S. Oh,
  • Neville S. Barrett,
  • Michael J. Emslie,
  • Amanda E. Bates,
  • Nic Bax,
  • Daniel Brock,
  • Antonia Cooper,
  • Tom R. Davis,
  • Paul B. Day,
  • Jillian C. Dunic,
  • Andrew Green,
  • Norfaizny Hasweera,
  • Jamie Hicks,
  • Thomas H. Holmes,
  • Ben Jones,
  • Alan Jordan,
  • Nathan Knott,
  • Meryl F. Larkin,
  • Scott D. Ling,
  • Peter Mooney,
  • Jacqueline B. Pocklington,
  • Yanir Seroussi,
  • Ian Shaw,
  • Derek Shields,
  • Margo Smith,
  • German A. Soler,
  • Jemina Stuart-Smith,
  • Emre Turak,
  • John W. Turnbull,
  • Camille Mellin
First published:September 22, 2022
With data from diver-based monitoring around Australia over the last decade, Stuart-Smith et al. reveal large-scale responses of reef fish communities to shifting ocean temperatures and habitat cover (corals and kelps). Warming impacts are observed in temperate zones and habitat loss impacts in tropical zones but with high spatial variability.

September 21, 2022

Report

ATM/ATR kinases link the synaptonemal complex and DNA double-strand break repair pathway choice

  • Laura I. Láscarez-Lagunas,
  • Saravanapriah Nadarajan,
  • Marina Martinez-Garcia,
  • Julianna N. Quinn,
  • Elena Todisco,
  • Tanuj Thakkar,
  • Elizaveta Berson,
  • Don Eaford,
  • Oliver Crawley,
  • Alex Montoya,
  • Peter Faull,
  • Nuria Ferrandiz,
  • Consuelo Barroso,
  • Sara Labella,
  • Emily Koury,
  • Sarit Smolikove,
  • Monique Zetka,
  • Enrique Martinez-Perez,
  • Monica P. Colaiácovo
First published:September 21, 2022
Láscarez-Lagunas et al. show DSB- and ATM/ATR-dependent phosphorylation of the SC structural component SYP-4 at S447 during meiosis. SYP-4 phosphorylation is important for maintaining the architectural integrity of the SC following exogenous DSBs, regulating CO patterning, and warding off repair via the NHEJ repair pathway to prevent aneuploidy.

September 20, 2022

Article

Lateral axonal modulation is required for stimulus-specific olfactory conditioning in Drosophila

  • Julia E. Manoim,
  • Andrew M. Davidson,
  • Shirley Weiss,
  • Toshihide Hige,
  • Moshe Parnas
First published:September 20, 2022
Open Access
Manoim et al. show that the abundant axo-axonic synapses between Kenyon cells in Drosophila mushroom body are mediated by muscarinic type-B receptors, which suppress Ca2+ and cAMP signals in neighboring cells. Since both signals are essential for synaptic plasticity, the lateral suppression enhances the stimulus specificity of associative learning.
Report

Octopus bimaculoides’ arm recruitment and use during visually evoked prey capture

  • Flavie Bidel,
  • Natalie C. Bennett,
  • Trevor J. Wardill
First published:September 20, 2022
Bidel et al. demonstrate that Octopus bimaculoides’ visually evoked prey capture strategies are prey dependent and arm recruitment is prey specific. Additionally, such observed arm recruitment principles enable the complexity of octopus’ arm motion control to be simplified through the dominant use of arm 2 and neighboring arm recruitment preferences.

September 19, 2022

Article

Genomic analysis reveals cryptic diversity in aphelids and sheds light on the emergence of Fungi

  • Kirill V. Mikhailov,
  • Sergey A. Karpov,
  • Peter M. Letcher,
  • Philip A. Lee,
  • Maria D. Logacheva,
  • Aleksey A. Penin,
  • Maksim A. Nesterenko,
  • Igor R. Pozdnyakov,
  • Evgenii V. Potapenko,
  • Dmitry Y. Sherbakov,
  • Yuri V. Panchin,
  • Vladimir V. Aleoshin
First published:September 19, 2022
Mikhailov et al. report the genomes of Amoeboaphelidium species, revealing vast divergence within the phylum Aphelida and confirming their close phylogenetic relationship to Fungi. Genomic analyses show the conservation of phagocytic proteins, expansions of receptor-like kinases, and evidence for horizontally transferred genes in aphelids.

September 16, 2022

Article

Arbuscular mycorrhizal fungi induce lateral root development in angiosperms via a conserved set of MAMP receptors

  • Chai Hao Chiu,
  • Pawel Roszak,
  • Martina Orvošová,
  • Uta Paszkowski
First published:September 16, 2022
Open Access
Plants produce more lateral roots when they engage in symbiosis with arbuscular mycorrhizal fungi. Chiu et al. show that this developmental response arises from increased organ primordia formation triggered by a broad range of chitin-derived compounds and requires a conserved chitin-receptor-like kinase across a broad range of plant species.
Article

Muscular hydraulics drive larva-polyp morphogenesis

  • Anniek Stokkermans,
  • Aditi Chakrabarti,
  • Kaushikaram Subramanian,
  • Ling Wang,
  • Sifan Yin,
  • Prachiti Moghe,
  • Petrus Steenbergen,
  • Gregor Mönke,
  • Takashi Hiiragi,
  • Robert Prevedel,
  • L. Mahadevan,
  • Aissam Ikmi
First published:September 16, 2022
Open Access
Stokkermans et al. show that the muscular-hydraulic system that controls body movement drives size and shape changes in the cnidarian Nematostella vectensis. Furthermore, organismal contractility and motility impact the dynamics of morphological changes. These data link animal behaviors and morphogenesis at both cellular and biophysical levels.

September 15, 2022

Report

Wildlife trade targets colorful birds and threatens the aesthetic value of nature

  • Rebecca A. Senior,
  • Brunno F. Oliveira,
  • James Dale,
  • Brett R. Scheffers
First published:September 15, 2022
Open Access
Senior et al. combine data on passerine plumage color with bird trade data, finding that unique coloration—prized by birdwatchers and typical of flagship species—is also associated with trade and extinction risk. The tropics are an epicentre of color, but loss of desirable species would erode aesthetic value and mute nature’s color palette.
Article

aPKC regulates apical constriction to prevent tissue rupture in the Drosophila follicular epithelium

  • Mariana Osswald,
  • André Barros-Carvalho,
  • Ana M. Carmo,
  • Nicolas Loyer,
  • Patricia C. Gracio,
  • Claudio E. Sunkel,
  • Catarina C.F. Homem,
  • Jens Januschke,
  • Eurico Morais-de-Sá
First published:September 15, 2022
Open Access
Osswald et al. use optogenetics and chemical genetics to rapidly modulate aPKC activity in Drosophila tissues and untangle its role as an inhibitor of apical actomyosin networks from its function in cell polarity. They show that acute induction of apical constriction rapidly leads to epithelial tissue rupture next to dividing cells in the fly ovary.
Article

A thalamo-preoptic pathway promotes social grooming in rodents

  • Dávid Keller,
  • Tamás Láng,
  • Melinda Cservenák,
  • Gina Puska,
  • János Barna,
  • Veronika Csillag,
  • Imre Farkas,
  • Dóra Zelena,
  • Fanni Dóra,
  • Stephanie Küppers,
  • Lara Barteczko,
  • Ted B. Usdin,
  • Miklós Palkovits,
  • Mazahir T. Hasan,
  • Valery Grinevich,
  • Arpád Dobolyi
First published:September 15, 2022
Social grooming is important for both individuals and to establish social communities. Keller et al. discover a thalamo-hypothalamic PIL-MPOA pathway critical for grooming between rodents and also demonstrate a similar pathway in the human brain. The pathway bypasses the cerebral cortex and thus might independently transmit unconscious pleasure.

September 14, 2022

Article

The genomic landscape of contemporary western Remote Oceanians

  • Lara R. Arauna,
  • Jacob Bergstedt,
  • Jeremy Choin,
  • Javier Mendoza-Revilla,
  • Christine Harmant,
  • Maguelonne Roux,
  • Alex Mas-Sandoval,
  • Laure Lémée,
  • Heidi Colleran,
  • Alexandre François,
  • Frédérique Valentin,
  • Olivier Cassar,
  • Antoine Gessain,
  • Lluis Quintana-Murci,
  • Etienne Patin
First published:September 14, 2022
Open Access
Although the settlement of Remote Oceania is now well understood, the population processes occurring in Vanuatu for the last 3,000 years remain unclear. Arauna et al. show that the fine-scale genetic structure of present-day ni-Vanuatu has been shaped by spatially uneven admixture, Polynesian migrations, volcano eruptions, and marriage patterns.
Article

A small proportion of X-linked genes contribute to X chromosome upregulation in early embryos via BRD4-mediated transcriptional activation

  • Qingji Lyu,
  • Qianying Yang,
  • Jia Hao,
  • Yuan Yue,
  • Xiaodong Wang,
  • Jianhui Tian,
  • Lei An
First published:September 14, 2022
Lyu et al. depict X chromosome upregulation (XCU) during mammalian preimplantation development. XCU initially occurs upon major ZGA and interplays with iXCI. A small proportion of X-linked genes contribute greatly to XCU via BRD4-mediated transcriptional activation. Preimplantation XCU is essential for the developmental potential of blastocysts.

September 13, 2022

Article

In vivo characterization of Drosophila golgins reveals redundancy and plasticity of vesicle capture at the Golgi apparatus

  • Sung Yun Park,
  • Nadine Muschalik,
  • Jessica Chadwick,
  • Sean Munro
First published:September 13, 2022
Open Access
Golgin coiled-coil proteins capture the vesicles that recycle Golgi residents. Park et al. relocate three Drosophila golgins to mitochondria to show that the content of intra-Golgi vesicles varies between tissues and in a golgin mutant. Such plasticity of Golgi organization could explain the synergistic effects of combining golgin null mutants.
Report

A method to soothe and promote sleep in crying infants utilizing the transport response

  • Nami Ohmura,
  • Lana Okuma,
  • Anna Truzzi,
  • Kazutaka Shinozuka,
  • Atsuko Saito,
  • Susumu Yokota,
  • Andrea Bizzego,
  • Eri Miyazawa,
  • Masaki Shimizu,
  • Gianluca Esposito,
  • Kumi O. Kuroda
First published:September 13, 2022
Open Access
Ohmura et al. investigate the effects of maternal holding and carrying on infant behavioral states (crying, alert, asleep) and identify that transport soothes crying infants and potentially promotes sleep. This study proposes “5-min carrying, 5- to 8-min sitting for bed” as an on-site behavioral intervention for infant crying and sleep difficulties.
Article

Differential coding of absolute and relative aversive value in the Drosophila brain

  • Maria E. Villar,
  • Miguel Pavão-Delgado,
  • Marie Amigo,
  • Pedro F. Jacob,
  • Nesrine Merabet,
  • Anthony Pinot,
  • Sophie A. Perry,
  • Scott Waddell,
  • Emmanuel Perisse
First published:September 13, 2022
Open Access
Optimal decision making requires animals to learn and use memories of absolute (good or bad) and relative (better or worse) experience. Villar et al. show that interaction between groups of valence-specific Drosophila dopaminergic neurons encodes absolute and relative aversive value teaching signals during learning.

September 12, 2022

Article

Spatial representation by ramping activity of neurons in the retrohippocampal cortex

  • Sarah A. Tennant,
  • Harry Clark,
  • Ian Hawes,
  • Wing Kin Tam,
  • Junji Hua,
  • Wannan Yang,
  • Klara Z. Gerlei,
  • Emma R. Wood,
  • Matthew F. Nolan
First published:September 12, 2022
Open Access
The retrohippocampal cortices are crucial for spatial memory. Tennant et al. show that neurons in the retrohippocampal cortices represent learned environments through ramping activity profiles. These profiles are distinct from well-studied discrete spatial firing fields and may be well suited to readout learned models of space.
Report

Maternal effects on early-life gut microbiota maturation in a wild nonhuman primate

  • Alice Baniel,
  • Lauren Petrullo,
  • Arianne Mercer,
  • Laurie Reitsema,
  • Sierra Sams,
  • Jacinta C. Beehner,
  • Thore J. Bergman,
  • Noah Snyder-Mackler,
  • Amy Lu
First published:September 12, 2022
Baniel et al. report on the gut microbiota maturation in a wild nonhuman primate, the gelada. Maternal effects shape the postnatal assembly of the gut microbiome during nursing and past the weaning transition. Such microbially mediated maternal effects could contribute to phenotypic plasticity in mammalian development.

September 9, 2022

Report

Braking slows passive flexion during goal-directed movements of a small limb

  • Sergio Rossoni,
  • Jeremy E. Niven
First published:September 09, 2022
Open Access
Rossoni and Niven show praying mantids make targeted forelimb reaches/searches incorporating tibial flexion. Passive forces, primarily from the flexor tibiae muscle, produce larger and faster flexion than during reaching. Consequently, targeted reaching requires active braking of passive tibial flexion, a novel control mechanism for a small limb.
Article

A unique inventory of ion transporters poises the Venus flytrap to fast-propagating action potentials and calcium waves

  • Sönke Scherzer,
  • Jennifer Böhm,
  • Shouguang Huang,
  • Anda L. Iosip,
  • Ines Kreuzer,
  • Dirk Becker,
  • Manfred Heckmann,
  • Khaled A.S. Al-Rasheid,
  • Ingo Dreyer,
  • Rainer Hedrich
First published:September 09, 2022
Scherzer et al. document the mechanism and molecular entities of the flytrap action potential. The authors present a model in which the contribution of glutamate receptor Ca2+ channels, R-type anion channels, SKOR K+ channels, H+ pumps, and H+-driven symporters to the different phases of the signal is determined.
Article

Genomic analyses of the Linum distyly supergene reveal convergent evolution at the molecular level

  • Juanita Gutiérrez-Valencia,
  • Marco Fracassetti,
  • Emma L. Berdan,
  • Ignas Bunikis,
  • Lucile Soler,
  • Jacques Dainat,
  • Verena E. Kutschera,
  • Aleksandra Losvik,
  • Aurélie Désamoré,
  • P. William Hughes,
  • Alireza Foroozani,
  • Benjamin Laenen,
  • Edouard Pesquet,
  • Mohamed Abdelaziz,
  • Olga Vinnere Pettersson,
  • Björn Nystedt,
  • Adrian C. Brennan,
  • Juan Arroyo,
  • Tanja Slotte
First published:September 09, 2022
Open Access
Gutiérrez-Valencia et al. identify the supergene that governs the iconic floral polymorphism of distyly in Linum. They show that the supergene harbors a 260-kb thrum-specific hemizygous region carrying a style-length candidate gene. These findings reveal striking convergence in the genetic architecture of independently evolved distyly supergenes.

September 8, 2022

Article

Evolutionarily conserved aspects of animal nutrient uptake and transport in sea anemone vitellogenesis

  • Marion Lebouvier,
  • Paula Miramón-Puértolas,
  • Patrick R.H. Steinmetz
First published:September 08, 2022
Open Access
In the sea anemone Nematostella vectensis, the vitellogenin-/apoB-expressing gonad epithelium exhibits high endocytosis and fatty acid translocation levels during vitellogenesis. Complementary expression of vldl receptor genes in oocytes supports that ECM-based lipoprotein transport is evolutionarily conserved between cnidarians and bilaterians.
Report

Rapid growth preceded gigantism in sauropodomorph evolution

  • Jennifer Botha,
  • Jonah N. Choiniere,
  • Roger B.J. Benson
First published:September 08, 2022
Sauropod dinosaurs achieved gigantic sizes via rapid, sustained growth. Botha et al. use new osteohistological evidence from two medium-sized transitional sauropodiform species to show rapid growth during early and mid-ontogeny. This indicates that increases in sauropodomorph growth rates evolved prior to the development of large body size.
Report

Avian neurons consume three times less glucose than mammalian neurons

  • Kaya von Eugen,
  • Heike Endepols,
  • Alexander Drzezga,
  • Bernd Neumaier,
  • Onur Güntürkün,
  • Heiko Backes,
  • Felix Ströckens
First published:September 08, 2022
In comparison to mammals, neuron densities in the avian brain are high, opening up the question of how birds can metabolically support their large neuron numbers. Von Eugen et al. show here that the neuronal energy budget of pigeons is about 3 times lower compared to mammals, possibly indicating a more efficient neuronal processing in the avian clade.
Article

Filopodial adhesive force in discrete nodes revealed by integrin molecular tension imaging

  • Ying Tu,
  • Kaushik Pal,
  • Jacob Austin,
  • Xuefeng Wang
First published:September 08, 2022
Tu et al. image filopodia adhesive force with single-molecule sensitivity. The force is distributed in a dot-like pattern with a spacing of ∼1 μm. Vinculin is dispensable for filopodia formation but required for the transmission of high-level molecular tensions in filopodia. Myosin X is not directly responsible for generating filopodia force.

September 7, 2022

Article

Reprogramming the topology of the nociceptive circuit in C. elegans reshapes sexual behavior

  • Vladyslava Pechuk,
  • Gal Goldman,
  • Yehuda Salzberg,
  • Aditi H. Chaubey,
  • R. Aaron Bola,
  • Jonathon R. Hoffman,
  • Morgan L. Endreson,
  • Renee M. Miller,
  • Noah J. Reger,
  • Douglas S. Portman,
  • Denise M. Ferkey,
  • Elad Schneidman,
  • Meital Oren-Suissa
First published:September 07, 2022
Open Access
Pechuk et al. study the circuit for nociceptive sensing and processing in hermaphrodite and male C. elegans. Combining circuit models and experimental characterization, they demonstrate that network topology shapes sexually dimorphic behavior. They show that simple rewiring reprograms behavior and demonstrates its sexual implications.
Report

Plant growth stimulation by high CO2 depends on phosphorus homeostasis in chloroplasts

  • Nadia Bouain,
  • Huikyong Cho,
  • Jaspreet Sandhu,
  • Patcharin Tuiwong,
  • Chanakan Prom-u-thai,
  • Luqing Zheng,
  • Zaigham Shahzad,
  • Hatem Rouached
First published:September 07, 2022
Bouain et al. report on how elevated atmospheric CO2 stimulates plant growth despite negatively impacting the accumulation of an essential plant nutrient, phosphorous (P). Studies in Arabidopsis and rice reveal that chloroplastic P transporters influence the accumulation of an anti-nutrient, phytic acid, and thereby growth capacity.

September 6, 2022

Article

Parallel encoding of CO2 in attractive and aversive glomeruli by selective lateral signaling between olfactory afferents

  • Dhruv Zocchi,
  • Emily S. Ye,
  • Virginie Hauser,
  • Thomas F. O’Connell,
  • Elizabeth J. Hong
First published:September 06, 2022
Zocchi et al. describe a novel form of stimulus-selective crosstalk between primary olfactory neurons in Drosophila. The subnetwork of selective lateral interactions enables new sensory computations that can dramatically reformat the spatial and temporal structure of odor input in a stimulus-specific manner.
Report

Regional cytoarchitecture of the adult and developing mouse enteric nervous system

  • Ryan Hamnett,
  • Lori B. Dershowitz,
  • Vandana Sampathkumar,
  • Ziyue Wang,
  • Julieta Gomez-Frittelli,
  • Vincent De Andrade,
  • Narayanan Kasthuri,
  • Shaul Druckmann,
  • Julia A. Kaltschmidt
First published:September 06, 2022
Open Access
The enteric nervous system spans the gastrointestinal (GI) tract and controls diverse GI functions, yet its structure is often characterized as a uniform meshwork. Hamnett et al. demonstrate that enteric neurons are organized into circumferential stripes that regionally differ in organization, development, and cellular composition.

September 2, 2022

Article

Micronuclei from misaligned chromosomes that satisfy the spindle assembly checkpoint in cancer cells

  • Ana Margarida Gomes,
  • Bernardo Orr,
  • Marco Novais-Cruz,
  • Filipe De Sousa,
  • Joana Macário-Monteiro,
  • Carolina Lemos,
  • Cristina Ferrás,
  • Helder Maiato
First published:September 02, 2022
Open Access
Gomes et al. use high-content live-cell imaging combined with RNAi to systematically investigate how human cells respond to chromosome alignment defects of distinct molecular nature. They find that misaligned chromosomes that satisfy the SAC are a strong predictor of micronuclei formation and may account for genomic instability in cancer.
Article

New Guinea uplift opens ecological opportunity across a continent

  • Emily Roycroft,
  • Pierre-Henri Fabre,
  • Anna J. MacDonald,
  • Craig Moritz,
  • Adnan Moussalli,
  • Kevin C. Rowe
First published:September 02, 2022
Roycroft et al. reconstruct the diversification of rodents (Murinae: Hydromyini) across New Guinea, Australia, and Melanesian islands since the Miocene. With species-level phylogenomic data, they show how geological processes, biome transitions, and over-water colonization drove diversification in an expansive continental radiation.

September 1, 2022

Report

A phylogenomically informed five-order system for the closest relatives of land plants

  • Sebastian Hess,
  • Shelby K. Williams,
  • Anna Busch,
  • Iker Irisarri,
  • Charles F. Delwiche,
  • Sophie de Vries,
  • Tatyana Darienko,
  • Andrew J. Roger,
  • John M. Archibald,
  • Henrik Buschmann,
  • Klaus von Schwartzenberg,
  • Jan de Vries
First published:September 01, 2022
Open Access
Hess et al. use comprehensive phylogenomic analyses and present a five-order system for the Zygnematophyceae. They place the filamentous and pyrenoid-lacking Mougeotiopsis among unicellular zygnematophytes. Based on this framework, they propose at least five independent origins of true filamentous growth for the closest relatives of land plants.
Article

Carbon-nitrogen trading in symbiotic nodules depends on magnesium import

  • Hong-Rui Cao,
  • Wen-Ting Peng,
  • Miao-Miao Nie,
  • Shuang Bai,
  • Chun-Qu Chen,
  • Qian Liu,
  • Zi-Long Guo,
  • Hong Liao,
  • Zhi-Chang Chen
First published:September 01, 2022
Cao et al. demonstrate that the GmMGT4&5-dependent magnesium import modulates carbon-nitrogen trading by regulation of plasmodesmal permeability in soybean nodules.

August 31, 2022

Article

Tonic activity in lateral habenula neurons acts as a neutral valence brake on reward-seeking behavior

  • Ryan J. Post,
  • David A. Bulkin,
  • R. Becket Ebitz,
  • Vladlena Lee,
  • Kasey Han,
  • Melissa R. Warden
First published:August 31, 2022
Post, Bulkin, et al. show that activity in lateral habenula (LHb) neurons is tonically elevated when mice take breaks from reward-seeking tasks. Elevated LHb activity is observed during task disengagements driven by negative (repeated reward omission) as well as positive (satiety) factors, and LHb inhibition extends reward-seeking behavioral states.
Article

A mechanism for red coloration in vertebrates

  • Matthew B. Toomey,
  • Cristiana I. Marques,
  • Pedro M. Araújo,
  • Delai Huang,
  • Siqiong Zhong,
  • Yu Liu,
  • Gretchen D. Schreiner,
  • Connie A. Myers,
  • Paulo Pereira,
  • Sandra Afonso,
  • Pedro Andrade,
  • Małgorzata A. Gazda,
  • Ricardo J. Lopes,
  • Ivan Viegas,
  • Rebecca E. Koch,
  • Maureen E. Haynes,
  • Dustin J. Smith,
  • Yohey Ogawa,
  • Daniel Murphy,
  • Rachel E. Kopec,
  • David M. Parichy,
  • Miguel Carneiro,
  • Joseph C. Corbo
First published:August 31, 2022
Red ketocarotenoid-based coloration is an important signal for many vertebrates. Toomey et al. describe a two-step enzymatic mechanism that mediates the production of ketocarotenoids in birds and fish. This work opens new avenues for understanding the evolution and function of red coloration in vertebrates.

August 30, 2022

Article

Genomes from a medieval mass burial show Ashkenazi-associated hereditary diseases pre-date the 12th century

  • Selina Brace,
  • Yoan Diekmann,
  • Thomas Booth,
  • Ruairidh Macleod,
  • Adrian Timpson,
  • Will Stephen,
  • Giles Emery,
  • Sophie Cabot,
  • Mark G. Thomas,
  • Ian Barnes
First published:August 30, 2022
Open Access
Brace et al. find that human remains recovered from a medieval well in Norwich, UK, have strong genetic affinities with modern-day Ashkenazi Jews and were likely victims of recorded antisemitic violence. The presence of Ashkenazi-associated genetic disease alleles indicates a pre-12th century population founder event.

August 29, 2022

Article

Membrane fission during bacterial spore development requires cellular inflation driven by DNA translocation

  • Ane Landajuela,
  • Martha Braun,
  • Alejandro Martínez-Calvo,
  • Christopher D.A. Rodrigues,
  • Carolina Gomis Perez,
  • Thierry Doan,
  • David Z. Rudner,
  • Ned S. Wingreen,
  • Erdem Karatekin
First published:August 29, 2022
Landajuela et al. show that the fission of a membrane neck during endospore formation in Bacillus subtilis results from an interplay between increasing membrane tension on one side of the neck and the accumulation of a cluster of FisB proteins inside it, impeding membrane flux and tension equilibration.

August 28, 2022

Report

Rapid evolution of pollen and pistil traits as a response to sexual selection in the post-pollination phase of mating

  • Jeanne Tonnabel,
  • Pascal Cosette,
  • Arnaud Lehner,
  • Jean-Claude Mollet,
  • Mohamed Amine Ben Mlouka,
  • Lucija Grladinovic,
  • Patrice David,
  • John R. Pannell
First published:August 28, 2022
Tonnabel et al. confirm the scope for sexual selection in the post-pollination phase of plant reproduction. Plants that evolved at a high plant density, which strengthens polyandry compared with low density, evolved faster-growing pollen tubes, upregulation of pollen proteins, and larger stigmas, which may conform to female choice processes.

August 26, 2022

Article

Distinct neural representations for prosocial and self-benefiting effort

  • Patricia L. Lockwood,
  • Marco K. Wittmann,
  • Hamed Nili,
  • Mona Matsumoto-Ryan,
  • Ayat Abdurahman,
  • Jo Cutler,
  • Masud Husain,
  • Matthew A.J. Apps
First published:August 26, 2022
Open Access
Actions that help others—prosocial behaviors—are vitally important for reducing the challenges to humanity. However, helping others requires effort, and people are effort averse. Using fMRI, Lockwood et al. show a distinct representation of prosocial effort in the anterior cingulate gyrus when deciding, and when exerting force, to help.

August 25, 2022

Article

A highly selective response to food in human visual cortex revealed by hypothesis-free voxel decomposition

  • Meenakshi Khosla,
  • N. Apurva Ratan Murty,
  • Nancy Kanwisher
First published:August 25, 2022
Using data-driven voxel decomposition on a large-scale naturalistic dataset, Khosla et al. discover a novel selectivity to visual images of food in the ventral visual cortex. This hypothesis-free approach also rediscovers neural selectivities to faces, bodies, scenes, and words, revealing their prominent role in the organization of the visual cortex.

August 24, 2022

Report

Nascent transcriptome reveals orchestration of zygotic genome activation in early embryogenesis

  • Hui Chen,
  • Matthew C. Good
First published:August 24, 2022
By profiling the nascent transcriptome during zygotic genome activation (ZGA) from whole Xenopus blastula and dissected subregions, Chen and Good unveil predominant transcription from maternal-zygotic genes and distinct spatial patterns, reconcile regulatory mechanisms of ZGA, and discover a link to sequential activation of germ-layer-specific genes.

August 23, 2022

Article

Ciliary flows in corals ventilate target areas of high photosynthetic oxygen production

  • Cesar O. Pacherres,
  • Soeren Ahmerkamp,
  • Klaus Koren,
  • Claudio Richter,
  • Moritz Holtappels
First published:August 23, 2022
Open Access
Pacherres, Ahmerkamp et al. present simultaneous measurements of flow and O2 in the coral boundary layer along with Chla content in the tissue beneath, showing a patchiness in the O2 distribution that is shifted away from O2-production zones by ciliary vortices; a mechanism that might help corals mitigate potential oxidative damage and bleaching.

August 22, 2022

Report

The transcription factor Tbx5 regulates direction-selective retinal ganglion cell development and image stabilization

  • Timour Al-Khindi,
  • Michael B. Sherman,
  • Takashi Kodama,
  • Preethi Gopal,
  • Zhiwei Pan,
  • James K. Kiraly,
  • Hao Zhang,
  • Loyal A. Goff,
  • Sascha du Lac,
  • Alex L. Kolodkin
First published:August 22, 2022
Little is known about the molecular code needed to specify different retinal ganglion cell types. Al-Khindi et al. show that the transcription factor Tbx5 is expressed by upward-preferring ON DSGCs and is required for their initial formation and the proper detection of vertical motion.
Report

Climate fluctuations influence variation in group size in a cooperative bird

  • Christina Riehl,
  • Zachariah Fox Smart
First published:August 22, 2022
A long-term study of a cooperatively breeding bird, the greater ani, reveals that small group sizes are favored in dry years, whereas larger groups are favored in wet years. Riehl and Smart find that variation in climate altered the costs and benefits of sociality, suggesting that fluctuating selection contributes to variation in group size.

August 19, 2022

Report

Ecology dictates the value of memory for foraging bees

  • Christopher D. Pull,
  • Irina Petkova,
  • Cecylia Watrobska,
  • Grégoire Pasquier,
  • Marta Perez Fernandez,
  • Ellouise Leadbeater
First published:August 19, 2022
Open Access
Using a maze designed to assay shorter-term memory in bees that later forage in the wild, Pull et al. find that high-performance bees are more efficient foragers in spring, when floral resources are rich, but not in summer, when resources are scarcer, challenging the notion that harsh environments primarily select for cognitive traits.
Article

The leaf beetle Chelymorpha alternans propagates a plant pathogen in exchange for pupal protection

  • Aileen Berasategui,
  • Noa Breitenbach,
  • Marleny García-Lozano,
  • Inès Pons,
  • Brigitte Sailer,
  • Christa Lanz,
  • Viterbo Rodríguez,
  • Katharina Hipp,
  • Nadine Ziemert,
  • Donald Windsor,
  • Hassan Salem
First published:August 19, 2022
Holometabolous insects must contend with antagonistic challenges during the immobile pupal stage. Berasategui et al. reveal that tortoise beetles rely on pupal protection from their fungal symbiont, Fusarium oxysporum. In exchange, the beetle propagates the fungus to naive host plants, extending the infection range of this plant pathogen.

August 18, 2022

Report

A single residue confers selective loss of sugar sensing in wrynecks

  • Julia F. Cramer,
  • Eliot T. Miller,
  • Meng-Ching Ko,
  • Qiaoyi Liang,
  • Glenn Cockburn,
  • Tomoya Nakagita,
  • Massimiliano Cardinale,
  • Leonida Fusani,
  • Yasuka Toda,
  • Maude W. Baldwin
First published:August 18, 2022
The sweet receptor has been ancestrally lost in birds. Cramer et al. show that, like hummingbirds and songbirds, woodpeckers independently gained sugar taste through modifications to the umami receptor; unexpectedly, within this group, the ant-specialist wrynecks have subsequently specifically lost sugar sensing through a single point mutation.

August 17, 2022

Article

Decoding perceptual awareness across the brain with a no-report fMRI masking paradigm

  • Elaheh Hatamimajoumerd,
  • N. Apurva Ratan Murty,
  • Michael Pitts,
  • Michael A. Cohen
First published:August 17, 2022
Open Access
Hatamimajoumerd et al. ask which parts of the brain support visual awareness. They find activation across the brain when observers report their experiences. However, without reports, the activation in the frontal lobe disappears. Meanwhile, with pattern classification, visibility can still be decoded in the frontal lobe even when no report is provided.

August 16, 2022

Article

High-sucrose diet exposure is associated with selective and reversible alterations in the rat peripheral taste system

  • Hayeon Sung,
  • Iva Vesela,
  • Hannah Driks,
  • Carrie R. Ferrario,
  • Charlotte M. Mistretta,
  • Robert M. Bradley,
  • Monica Dus
First published:August 16, 2022
Sung et al. show that elevated dietary sucrose decreases the responses of the chorda tympany nerve to sucrose. The morphology of the fungiform papilla and the number, size, and innervation of the taste buds were unaffected, but the number of PLCβ2+ cells was lower. These selective effects were restored when sucrose was removed from the diet.
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