Developmental Cell
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New articles

Articles below are published ahead of final publication in an issue. Please cite articles in the following format: authors, (year), title, journal, DOI.

September 30, 2022


Pluripotency factors are repurposed to shape the epigenomic landscape of neural crest cells

  • Austin S. Hovland,
  • Debadrita Bhattacharya,
  • Ana Paula Azambuja,
  • Dimitrius Pramio,
  • Jacqueline Copeland,
  • Megan Rothstein,
  • Marcos Simoes-Costa
First published:September 30, 2022
Utilizing genomic analysis to survey neural crest development, Hovland and Bhattacharya et al. identify Yamanaka factors OCT4 and SOX2 as key regulators of multipotency. The authors show how components of the pluripotency network cooperate with tissue-specific pioneer transcription factors to generate the neural crest stem cell state.

Cyclin B3 implements timely vertebrate oocyte arrest for fertilization

  • Nora Bouftas,
  • Lena Schneider,
  • Marc Halder,
  • Rebecca Demmig,
  • Martina Baack,
  • Damien Cladière,
  • Melanie Walter,
  • Hiba Al Abdallah,
  • Camilla Kleinhempel,
  • Ria Messaritaki,
  • Janina Müller,
  • Francesca Passarelli,
  • Patrick Wehrle,
  • Andreas Heim,
  • Katja Wassmann,
  • Thomas U. Mayer
First published:September 30, 2022
Vertebrate oocytes must arrest at the second meiotic division for successful fertilization. Bouftas and Schneider et al. find that correct timing of this arrest depends on the oocyte-specific cyclin B3. Together with Cdk1, cyclin B3 specifically targets Emi2 for degradation in the first meiotic division, thus preventing precocious arrest.

September 28, 2022


ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains

  • Muhammad U. Anwar,
  • Oksana A. Sergeeva,
  • Laurence Abrami,
  • Francisco S. Mesquita,
  • Ilya Lukonin,
  • Triana Amen,
  • Audrey Chuat,
  • Laura Capolupo,
  • Prisca Liberali,
  • Giovanni D’Angelo,
  • F. Gisou van der Goot
First published:September 28, 2022
Open Access
Anwar et al. show that organization of the plasma membrane into nanodomains, which are required for anthrax intoxication, depends on the transfer of cholesterol at sites where the endoplasmic reticulum and the Golgi contact each other. This transfer depends on a protein supercomplex that is organized by two proteins, TMED2 and TMED10.

A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration

  • Naoya Hino,
  • Kimiya Matsuda,
  • Yuya Jikko,
  • Gembu Maryu,
  • Katsuya Sakai,
  • Ryu Imamura,
  • Shinya Tsukiji,
  • Kazuhiro Aoki,
  • Kenta Terai,
  • Tsuyoshi Hirashima,
  • Xavier Trepat,
  • Michiyuki Matsuda
First published:September 28, 2022
Hino et al. find that during collective cell migration, leader and follower cells show sustained and oscillatory ERK activation, respectively. They demonstrate that a positive feedback loop between free edge-dependent lamellipodial extension and HGF-Met-ERK activation underlies the sustained ERK activation and thereby leader cell specification.