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Neuron
This journal offers authors two options (open access or subscription) to publish research

Apr 10, 2013

Volume 78Issue 1p1-206
Open Archive
On the cover: Fire and ice dragons battle in the spinal cord with extreme forms of heat and cold. In this issue, McCoy et al. (pages 138–151) genetically ablated CGRPα-expressing somatosensory neurons, creating mice with reduced sensitivity to heat and itch but enhanced sensitivity to cold. Studies with these mice reveal that CGRPα/heat-sensing neurons cross-inhibit spinal neurons associated with cold. The dragons symbolize these heat- and cold-sensitive somatosensory circuits and their inhibitory interaction in the spinal cord. Concept by Mark Zylka; artwork by Carlos Herrera Portilla (http://carloxherrera.daportfolio.com)....
On the cover: Fire and ice dragons battle in the spinal cord with extreme forms of heat and cold. In this issue, McCoy et al. (pages 138–151) genetically ablated CGRPα-expressing somatosensory neurons, creating mice with reduced sensitivity to heat and itch but enhanced sensitivity to cold. Studies with these mice reveal that CGRPα/heat-sensing neurons cross-inhibit spinal neurons associated with cold. The dragons symbolize these heat- and cold-sensitive somatosensory circuits and their inhibitory interaction in the spinal cord. Concept by Mark Zylka; artwork by Carlos Herrera Portilla (http://carloxherrera.daportfolio.com).

Previews

Reviews

  • Modeling Autism by SHANK Gene Mutations in Mice

    • Yong-hui Jiang,
    • Michael D. Ehlers
    Genetic studies implicate SHANK genes in autism spectrum disorders. Several mutant mouse lines have been generated with biochemical, synaptic, and behavioral deficits. Jiang and Ehlers review the complex genetics of SHANK variants and genotype-phenotype relationships in humans and mouse models.
  • Synaptic Computation and Sensory Processing in Neocortical Layer 2/3

    • Carl C.H. Petersen,
    • Sylvain Crochet
    Petersen and Crochet review recent advances in the understanding of cell type-specific synaptic circuits driving neocortical layer 2/3 networks gained through application of new optical, electrophysiological, behavioral, and genetic techniques.

Reports

  • Proteoglycan-Mediated Axon Degeneration Corrects Pretarget Topographic Sorting Errors

    • Fabienne E. Poulain,
    • Chi-Bin Chien
    Proper arrangement of axonal projections into topographic maps is crucial for brain function. Poulain and Chien find that selective axon degeneration is a corrective mechanism that eliminates missorted axons in the zebrafish optic tract during development, and heparan sulfate is a key regulator of this process.
  • Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels

    • Fernando Bartolome,
    • Hsiu-Chuan Wu,
    • Victoria S. Burchell,
    • Elisavet Preza,
    • Selina Wray,
    • Colin J. Mahoney,
    • Nick C. Fox,
    • Andrea Calvo,
    • Antonio Canosa,
    • Cristina Moglia,
    • Jessica Mandrioli,
    • Adriano Chiò,
    • Richard W. Orrell,
    • Henry Houlden,
    • John Hardy,
    • Andrey Y. Abramov,
    • Helene Plun-Favreau
    In this study, Bartolome et al. show that three independent pathogenic VCP mutations induce mitochondrial uncoupling, resulting in low cellular ATP production, rendering the cells more susceptible to cell death under stress-induced ischemic conditions.

Articles

Errata

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