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Neuron
This journal offers authors two options (open access or subscription) to publish research

Dec 06, 2017

Volume 96Issue 5p951-1204
Open Archive
On the cover: Regeneration failure in neurological diseases is attributed to a hostile environment that is not permissive to repair. Petersen et al. (pages 1003–1012) identified the coagulation factor fibrinogen as an upstream blood-derived signal that inhibits OPC maturation and remyelination. They found that fibrinogen activates BMP receptor signaling in oligodendrocyte progenitor cells and it can be targeted therapeutically to promote remyelination. This image represents extravasation of fibrinogen in the brain through a damaged brain blood vessel leading to a dysregulated neurovascular progenitor niche and a non-permissive environment for repair. Artwork by Ella Marushchenko and Elina Karimullina (Ella Maru Studio)....
On the cover: Regeneration failure in neurological diseases is attributed to a hostile environment that is not permissive to repair. Petersen et al. (pages 1003–1012) identified the coagulation factor fibrinogen as an upstream blood-derived signal that inhibits OPC maturation and remyelination. They found that fibrinogen activates BMP receptor signaling in oligodendrocyte progenitor cells and it can be targeted therapeutically to promote remyelination. This image represents extravasation of fibrinogen in the brain through a damaged brain blood vessel leading to a dysregulated neurovascular progenitor niche and a non-permissive environment for repair. Artwork by Ella Marushchenko and Elina Karimullina (Ella Maru Studio).

Previews

Obituary

  • John Lisman (1944–2017)

    • Ole Jensen,
    • Marco Idiart
    On October 20, 2017, John Lisman sadly passed. Being very ill did not hinder his determination, as he was continuing full speed in his research, keeping several collaborations in parallel, writing papers, and giving talks until the very last moment. Impressively, John gave an excellent talk on his work on synaptic plasticity at Brandeis University from his hospital bed in the ICU. In his long scientific career, John made numerous scientific contributions that have shaped the field of neuroscience, spanning from novel insights on second-messenger cascades to human memory.

NeuroView

  • A Commitment to Open Source in Neuroscience

    • Padraig Gleeson,
    • Andrew P. Davison,
    • R. Angus Silver,
    • Giorgio A. Ascoli
    Should custom software that is essential to reproducing results of publications be publicly released? Arguing that it must, Gleeson et al. have, together with other researchers, signed a commitment to releasing their code and will ask the same upon peer review.

Primer

  • Pushing the Boundaries of Neuroimaging with Optoacoustics

    • Saak V. Ovsepian,
    • Ivan Olefir,
    • Gil Westmeyer,
    • Daniel Razansky,
    • Vasilis Ntziachristos
    Ovsepian et al. review the state of the art in optoacoustic (photoacoustic) neuroimaging and discuss emerging experimental capabilities and limitations. Multiple implementations at different imaging scales and resolutions are considered in the context of present-day and future studies.

Review

  • Getting a Handle on Neuropharmacology by Targeting Receptor-Associated Proteins

    • Michael P. Maher,
    • Jose A. Matta,
    • Shenyan Gu,
    • Mark Seierstad,
    • David S. Bredt
    Effective treatments for neuropsychiatric disorders require selective modulation of dysfunctional circuits. This review by Maher et al. outlines a strategy for targeting neurotransmitter receptor-associated proteins. This innovative pharmacological approach promises to enhance drug efficacy and minimize side effects.

Reports

  • Fibrinogen Activates BMP Signaling in Oligodendrocyte Progenitor Cells and Inhibits Remyelination after Vascular Damage

    • Mark A. Petersen,
    • Jae Kyu Ryu,
    • Kae-Jiun Chang,
    • Ainhoa Etxeberria,
    • Sophia Bardehle,
    • Andrew S. Mendiola,
    • Wanjiru Kamau-Devers,
    • Stephen P.J. Fancy,
    • Andrea Thor,
    • Eric A. Bushong,
    • Bernat Baeza-Raja,
    • Catriona A. Syme,
    • Michael D. Wu,
    • Pamela E. Rios Coronado,
    • Anke Meyer-Franke,
    • Stephanie Yahn,
    • Lauriane Pous,
    • Jae K. Lee,
    • Christian Schachtrup,
    • Hans Lassmann,
    • Eric J. Huang,
    • May H. Han,
    • Martina Absinta,
    • Daniel S. Reich,
    • Mark H. Ellisman,
    • David H. Rowitch,
    • Jonah R. Chan,
    • Katerina Akassoglou
    Extrinsic inhibitors contribute to remyelination failure in neurological diseases. Petersen et al. identify the blood coagulation factor fibrinogen as an activator of BMP receptor signaling in oligodendrocyte progenitor cells that may be targeted therapeutically to promote remyelination.
  • Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis

    • Tien-Phat V. Huynh,
    • Fan Liao,
    • Caroline M. Francis,
    • Grace O. Robinson,
    • Javier Remolina Serrano,
    • Hong Jiang,
    • Joseph Roh,
    • Mary Beth Finn,
    • Patrick M. Sullivan,
    • Thomas J. Esparza,
    • Floy R. Stewart,
    • Thomas E. Mahan,
    • Jason D. Ulrich,
    • Tracy Cole,
    • David M. Holtzman
    Huynh et al. demonstrated that apoE3 and apoE4 are critical factors in promoting amyloidosis during the early stages of Aβ plaque formation but not during the exponential growth phase. Importantly, reduction of apoE4 decreases neuritic dystrophy independent of Aβ pathology.
  • ApoE4 Accelerates Early Seeding of Amyloid Pathology

    • Chia-Chen Liu,
    • Na Zhao,
    • Yuan Fu,
    • Na Wang,
    • Cynthia Linares,
    • Chih-Wei Tsai,
    • Guojun Bu
    Liu et al. have developed cell-type-specific and inducible apoE mouse models and demonstrate that astrocytic apoE4 is a potent factor in promoting amyloidosis during the seeding stage, but not the rapid growth period, of amyloid development. ApoE4 impairs Aβ clearance and accelerates Aβ aggregation, leading to enhanced amyloid pathology and neuritic dystrophy.
  • Kinetics of Releasable Synaptic Vesicles and Their Plastic Changes at Hippocampal Mossy Fiber Synapses

    • Mitsuharu Midorikawa,
    • Takeshi Sakaba
    Midorikawa and Sakaba combined electrophysiological recordings and total internal reflection microscopy and revealed the dynamics of synaptic vesicles at hippocampal mossy fiber boutons in basal and cAMP-potentiated states, which may be relevant for LTP.

Articles

Corrections

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