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Trends in Cancer
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Cross-dressing of dendritic cells strengthens antitumor immunity

  • Author Footnotes
    3 The authors contributed equally to this work.
    Hongli Yin
    Footnotes
    3 The authors contributed equally to this work.
    Affiliations
    CAMS Key Laboratory of Synthetic Biology Regulatory Element, Institute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China

    Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China
    Search for articles by this author
  • Author Footnotes
    3 The authors contributed equally to this work.
    Hongcheng Cheng
    Footnotes
    3 The authors contributed equally to this work.
    Affiliations
    CAMS Key Laboratory of Synthetic Biology Regulatory Element, Institute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China

    Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China
    Search for articles by this author
  • Yuqian Wang
    Affiliations
    CAMS Key Laboratory of Synthetic Biology Regulatory Element, Institute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China

    Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China
    Search for articles by this author
  • Guideng Li
    Correspondence
    Correspondence:
    Affiliations
    CAMS Key Laboratory of Synthetic Biology Regulatory Element, Institute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China

    Suzhou Institute of Systems Medicine, Suzhou, Jiangsu 215123, China
    Search for articles by this author
  • Author Footnotes
    3 The authors contributed equally to this work.
Published:January 31, 2022DOI:https://doi.org/10.1016/j.trecan.2022.01.001
      Different subsets of tumor-infiltrating dendritic cells (DCs) influence immune response and tolerance in cancer settings. Duong et al. discovered that conventional DC2 subset (cDC2s) can differentiate into stimulatory interferon-stimulated gene (ISG)+ DCs by type I interferon (IFN-I) produced in regressor tumors and acquire and present tumor-derived peptide-MHC (pMHC) class I complexes to increase the protective antitumor CD8+ T cell response.

      Keywords

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